Series with the first letter - "S"
- Significant Others (2022–…)
- Silence (2021–…)
- Silent Witness (1996–…)
- Silicon Valley (2014–…)
- Silicon Valley: The Untold Story (2018)
- Silk (2011–2014)
- Silk Stalkings (1991–1999)
- Silver Spoons (1982–1987)
- Silver Surfer (1998)
- Silverhawks (1986–…)
- Silverpoint (2022–…)
- Simon & Simon (1981–1989)
- Simon Schama's Power of Art (2006–…)
- Sinatra: All or Nothing at All (2015–…)
- Sinbad (2012–2013)
- Single by 30 (2016–…)
- Single Drunk Female (2022–…)
- Single Father (2010–…)
- Single Ladies (2011–…)
- Single Parents (2018–…)
- Single's Inferno (2021–…)
- Sintonia (2019–…)
- Siren (2018–…)
- Sirens (2014–2015)
- Sirens (2011–…)
- Sirius the Jaeger (2018–…)
- Sisi (2021–…)
- Sistas (2019–…)
- Sister Boniface Mysteries (2022–…)
- Sister, Sister (1994–1999)