Pure Genius (2016–2017): Season 1, Episode 7 - A Bunker Hill Christmas - full transcript

Previously on Pure Genius...

When I opened Bunker Hill
I made a promise that I would do

everything humanly possible
to save everyone

who came through these doors.

I want to be part of this.

Julianna Wallace, Executive Consumer
Safety Officer for the FDA.

You married up, W.

- You kissed me.
- Really?

This is Louis Keating.

He's been diagnosed with
Gerstmann-Straussler-Scheinker disease.

It's like ALS on steroids.



I did have
the genetic test done,

and it came back positive
for GSS.

I'm so sorry, James.

♪ We fly ♪

♪ over mountains and ride ♪

♪ through the sunset ♪

♪ I'm just so excited ♪

♪ when I got you by my side. ♪

This is Madeline Sorenson
from Wichita, Kansas.

She's 15 years old,
high-risk acute myeloid leukemia.

Terminal.

- She's been everywhere.
- I've checked her scans and her history.

Unfortunately, James,
there's not much

we can do for this patient.



Well, what about...
CAR T-cell therapy?

It's brand-new,
and we've been given approval

for a one-time trial through the
FDA's Compassionate Use program.

Cytotoxic T-cells.

The green berets of
our immune system.

- Exactly.
- James, it's shown a lot of promise

in fighting lymphoid-type
blood cancers, but this type

of leukemia, it's
a different beast altogether.

Unfortunately, T-cells
don't have antibody detectors

that fit into a protein on the
surface of the leukemia cell.

Which is why we're...
gonna engineer one.

Well, we'd have to design a very
specific key, which could take time.

And her latest labs
are not good.

Hemoglobin: 5.8;
Platelets: 64.

She has a month,
maybe two at best.

Okay, I get it,
it's a Hail Mary pass, but...

Before I hear
all the naysayers speak up,

let me remind you of two things.

This face.

And it's Christmas week.

Okay, naysayers, speaketh.

Yeah. Let's bring her in.

Why not?

Tina, send the plane
for Maddie and her family.

And Merry Christmas, everyone.

And, Rebecca,

Happy Hanukkah. Shalom.

And...

Christian.

So we're all covered.
Good. Carry on.

Dr. Verlaine.

May I have a word?

Yes.

Um... About that kiss.

- What kiss?
- Our kiss.

- A few weeks ago.
- I'm joking.

Oh. Right. Hmm.

It's amusing.

So, as I said,
I was sleep-deprived,

I wasn't thinking straight,
and we had just attended

- a wedding...
- Look, I hear it.

Let's just forget
that it ever hap...

But upon further review,
I realize it was not

entirely fair to make you feel
like it was all one-sided,

so I take...

some responsibility
for what happened.

Look, Brockett,

it's kind of hard to have
a conversation here.

- Mm-hmm.
- What if

we grab dinner off campus?

Di... dinner?

Yeah.

- Talk this through.
- I'll do brunch.

Brunch works.

Okay. Good.
Thank you, Dr. Verlaine.

Dr. Brockett.

You see this woman?

Andrea Cocciano.

Born Andrew Cocciano.

She identified as a woman

from the time
she was six years old.

She's brilliant.
MBA from Harvard.

And she's about to be fired

by a major equities firm
because she's transgender.

This is a precedent-setting case

of national importance.
I can win this.

But I need your help
to cure me first.

We are well aware of your work
as a civil rights attorney.

I have to admit, I'm a fan.

Thank you.
Okay, let's talk quickly,

'cause I'm a ticking time bomb.

I wasn't diagnosed
until six months ago.

The theory is I've had
these petit mal seizures

my whole life.
As a child,

they would come and go,
but they never affected me.

Now I have an average
of ten per hour.

I can't go to trials like this.

I can barely even get through
a deposition at this point.

I need someone to take the bull

by the horns
or I am out of business.

And so are all the people
who are depending on me

to feel heard and represented.

It just happened, didn't it?

Let's give him

another course of Gent and
make sure to monitor his creatinine.

- Yes, Doctor.
- Thank you.

- Merry Christmas, Dr. Wallace.
- Honey.

Yes, it is.

- What-what are you doing here?
- Oh, well,

I know that you only had
two days over Christmas,

so I... played around
with my schedule.

I don't want you to be alone
over the holidays.

This is a wonderful surprise.

And don't worry,
I brought plenty of my own work.

In fact, some of it is,
uh, right here.

- Here?
- Yeah, Bunker Hill

has a request to, uh,
approve a trial for a drug for GSS,

Gerstmann-Straussler-Scheinker
syndrome.

I know about the trial.

I would normally have somebody else
at the office do it,

- but I pulled a few strings and here I am.
- Well, we're gonna have

- a wonderful holiday.
- BFF!

What on earth
are you doing here?

Hi, James.

Are you here for
business or pleasure?

Actually, I'm here for the
presentation on the GSS trial.

Oh. Wonderful.

Didn't know the FDA would send out
the big guns for our tiny little study.

May I borrow your husband
for just a moment?

- Sure.
- Yeah.

Perseus, would you help
Julianna with her luggage?

- I'll take your bags for you.
- Oh, thank you.

Wish you'd mentioned
that the Grim Reaper

was coming here to
ruin our GSS trial.

I was expecting to get someone
lower on the food chain

- so I could push it through.
- I had no idea she was coming.

But don't call her that the
Grim Reaper, even if it's a joke.

- I felt it, W.
- You felt what?

- The tremor.
- What kind of tremor?

A not particularly distinguishable
tremor in my right hand.

Tremors are typically the
first signs of the symptoms of GSS

- taking a hold on the human body.
- James...

Mild tremors followed
by more intense tremors

followed by tics
to slowing of the muscles

to attacking and eventually
destroying of the brain.

I felt it, W.

I don't want you to jump
to any conclusion...

W...

Will you be my doctor?

Of course.

Excellent.

Ah, here she is.

You must be Maddie.

You must be James Bell.

Hi. I'm Dr. Wallace.
Nice to meet you all.

Hi. Thank you so much
for accepting

- our application.
- Nice to meet you.

Are you ready to kick
your cancer's ass?

So ready.

Let's get you checked in.

Welcome to Bunker Hill.

Right this way.

Today we have proven that
this public elementary school

knowingly put
its own students' health at risk

by using a food vendor
that provided absolutely zero

food choices that met
with FDA nutritional standards.

And the court ruling today
comes a long way

to once and for all stop

these profit-seeking
food vendors

from harming
our nation's children.

- That lady is good.
- Giselle Overman has

become a voice in this country
for people without a voice.

Her petit mal seizures
have increased

in intensity and frequency
to the point where

she no longer can function
in her daily life.

- What can we do?
- I call it

the neural pacemaker.

I borrowed technology
from the cardiac pacemaker.

The neural pacemaker

monitors electrical
activity in the brain.

When the cluster of neurons

responsible for a seizure start
to show increased activity,

it basically snuffs out the seizure
before it occurs.

Be still my heart.

When can we install that puppy?

There's a hitch.

I've done a functional MRI,
a diffusion MRI and an EEG,

and I haven't been able to
isolate the area of her brain where

the seizure cascade begins.

So we have a fix,
but without a seizure focus,

- we can't use it.
- How do we find the focus?

Without a new way to look
at the brain, I have no idea.

So find a new way
to look at the brain.

Obviously.

Obviously.

These are projections
of Maddie's cancer cells

from the bone marrow
you collected.

So that protein is the lock.

Exactly. But we're working
on a key. The problem is

the leukemia protein
has a similar structure

to a lot of the other
proteins in the body,

so making our key fit that lock

and only that lock
hasn't been easy.

Elody, how's it going?

I can show you something
in one minute.

So, how's the Malik sitch?

He asked me to dinner.

- And?
- I panicked... I said brunch.

Ooh. The brunch downgrade.
Been there.

Exactly. I just thought,
take it slow, you know?

It's not like a date or
anything... it's brunch,

- it's casual.
- Please, I don't care

if it's a five-course meal
or an Egg McMuffin...

Once food is being ingested,
it's a date.

- So you're saying I shouldn't go to brunch?
- No, I'm saying you're going on a date.

Yeah, I agree.

It's definitely a date.
Here, check this out.

So, these are Maddie's T-cells,
which we've modified

by adding our artificial
antibody detector.

The blue ones are
her modified T-cells,

and the red ones are
her leukemia cells.

Oh, my God.

This might actually work.

So...

You're infusing me
with some kind of GMO,

which means if this works and,
you know, I actually live,

I will never be able to walk
into a Whole Foods again.

Not exactly. Um, these
are your actual cells.

We're just giving them
the enhanced ability

to detect your leukemia cells.

Hmm. So, super cells.

Yeah, super cells.

Do your work, super cells.

You ready to pick a little?

Pick? Oh, yeah, no.

Uh, not a picker.

Then I'll play, you sing.

No.

Maddie, I don't think
that's a good idea

for anyone involved.

Dr. Brockett,

I have been to...

five hospitals
in four different cities

over the past two years.

I mean, my life has just been
about staying alive.

So whenever someone
sticks a needle in me

or does a scan
or pokes me or prods me,

doing music is
what gets me through it.

So I'm afraid
I'm gonna have to insist.

I promise you
you're gonna regret this.

- Uh-huh.
- Mm-hmm.

♪ If you are falling ♪

- ♪ then I would catch you ♪
- Catch... uh, I can't.

♪ If you need a light ♪

♪ I'd find a match ♪

♪ 'cause I ♪

♪ love the way you say
good morning ♪

♪ and you take me the way I am ♪

- Mm-hmm!
- Okay.

♪ If you are chilly ♪

♪ here, take my sweater ♪

♪ If your head is aching ♪

♪ I'll make it better ♪

♪ 'cause I ♪

♪ love the way ♪

♪ you call me baby ♪

♪ and you take me the way I am ♪

Oh, wow.

Okay, this takes me
back to the old days.

Does it kind of remind you
of the office they gave me

when I was a surgical intern
at the Cleveland Clinic?

Mm-hmm. I remember

showing up at midnight,
because if I didn't

I would never get to see you.

If I recall, some
of those visits

- weren't half bad.
- Mmm.

I think I figured out how...

I am so sorry.
I'll come back.

No, it's okay.
This is my wife, Julianna.

Jules, this is
Dr. Channarayapatra,

my, um, office mate.

Oh. Uh, Dr...?

Channarayapatra.
Oh, it's-it's...

It's wonderful to meet you.

I have heard so much
about you and the kids.

Oh, thank you.

I will leave you two, to, uh...

To carry on.

Find me later.

Please, this is your
office; It's... well,

it's both of your
offices, right?

So, please, go ahead.

Okay.

I was just thinking,

maybe we don't actually
need to find a new way

of imaging the brain.
We need a new way

to process the data we've
already gotten from the brain.

So what if we took

the fMRI, which localizes
brain functions and laid it...

Laid it over the EEG,

which would give us a picture
of the seizure activity.

That should point us to the
right area of the brain.

Exactly. And if we merged
that composite image

with the Diffusion Tensor MRI,

we should be able
to follow the neural pathway

back to the seizure focus.

Then we could see
the seizure manifest

itself in real time
in three dimensions.

This is brilliant.

Sounds like writing
some tricky software.

I'll talk to James.

He could do it in his sleep.

- It's great to meet you.
- Oh, you, too.

Just... just tell us
if it isn't working.

We can handle bad news.

It's good news.

Wait. It is? Really?

In fact, it's looking a little
bit like a Christmas miracle.

Oh, my God.

Her numbers improved?

These are your latest numbers.

Your white cell count is 11,000.

11,000?

- Are you serious?
- Oh, my God.

I was at 45,000.

Nothing we've done
has ever brought

- her white cell count down.
- This is far better and faster

than anything we could
have ever imagined.

Oh, my God.

See?

It was because you sang with me.

I mean, you're my
good luck charm.

No, I'm not.

Oh, baby.

You guys are the best.

Uh, James.

Uh, not to get
ahead of ourselves,

but there's a concert
coming up in a couple of weeks,

Phillip Phillips is playing.

He's been a huge hero to Maddie
throughout all of this.

I want to buy tickets,

but I need to know if
there's any way you think

she's gonna be
strong enough to go.

Don't buy the tickets.

Okay.

Let me.

I hear the FDA is here to
rule on the treatment for GSS.

Yes.

What are the chances
of getting approved?

I feel our chances
are sky-high, Louis.

Bishop to queen's rook five.

Louis, the bishop
doesn't move that way.

It moves diagonally.

GSS is caused by abnormally
folded proteins

called prions
building up in the brain.

These prions stick
together in clusters

called oligomeric aggregates,

which are toxic to brain cells.

We've been working
on a new medication

called PAI 120b.

It's a prion aggregate
inhibitor.

This drug sticks to these
abnormal prion proteins

so they can't clump together
in these toxic aggregates.

We've been producing it right here
in our pharmacologic sciences lab.

It's in compliance
with all FDA standards.

Our patient, Louis Keating,
is getting worse.

This disease is attacking
his body and his mind,

and before long,

even his shadow of an existence

will come to an end.

But our drug has a chance
to change all that.

Worst case scenario, this is a huge leap
towards curing this insidious illness.

Best case scenario,
we give a man his life back.

I-I mean, this is just
a remarkable presentation.

It's one of the strongest applications I've
seen for a Phase One Clinical Drug trial.

Great. So we can move
towards human trials.

But it's not ready yet.

You have eight weeks of safety data
in your animal models,

and I totally agree the numbers
are really promising,

but, James,
that's only eight weeks.

But we have a patient here
who has an urgent need.

I'm sorry.

I need more data
from the animal models

for approval of a human trial.

You're looking at six
to 12 months, at least.

This is for you.

Hmm.

Oh, my God.

These are first row tickets
to Phillip Phillips.

Mm-hmm.

No.

And backstage passes?

- Mm-hmm.
- But how did you know?

Your dad told me.

Wait, so you think
I'll actually be able to go?

I'm very hopeful.

Oh, my God.

- Do you know what I was just doing?
- No.

I was writing a song.

I mean, I-I stopped writing
songs five months ago,

because what was the point,
you know?

But for the first time
in so long,

I can actually see past
being a patient.

So...

Tell me, Maddie,
what's in your five-year plan?

I have this stupid fantasy, really,

that one day,
I'll open up for Phillip Phillips

and, you know, he'd invite me
on stage and we'd sing a song.

♪ Just know you're not alone ♪

♪ 'cause I'm gonna make
this place your home. ♪

Sorry. I know it's so dumb.

- Sorry.
- It's not dumb at all.

I really should go
to a concert some day.

- You've never been to a concert before?
- Not really.

- How is that even possible?
- I don't know.

I always thought I wanted
to go see Beta Band,

but then, uh,
I heard they broke up.

So what's your five-year plan, then?

You know, after you've saved
everyone's life on the planet.

What are you gonna do then,
James Bell?

Well, I guess if you're
really asking, uh...

When I was a kid, I'd walk
through my neighborhood

and I'd look through the windows,
and I'd see all these families

gathered together around
the TV, and I thought,

- that looks really beautiful.
- Mmm.

My mom used to
work a lot, and, uh,

when she was home

we could never
agree on a TV show.

So I watched alone.

So I guess when I
grow up, what I want

is to have a family
to watch TV with.

Do you have someone
to do that with?

No.

I mean... uh...

I have this stupid idea, but...

But what?

I wouldn't even know
where to start.

Well, maybe start
with what you just said,

because it was awesome.

Brockett.

James.

I've never been to a concert.

- Oh?
- Ever.

I don't know why, I like music.

I just like to be
able to hear the song

that I want to hear
when I want to hear it.

The idea of having
to watch a band

and hope that they play
the song I want to hear

just seems so frustrating.

What if I'm sitting next
to some drunk person

who keeps trying to lean on me?

Or someone who has to
sing along to every word

at the top of their lungs?

You know, James, if you're
not enjoying a concert

you can always just leave.

This has nothing to do
with concerts, Brockett.

- Oh, it doesn't?
- Concerts is just one example.

I'm talking about life.

About watching TV
with your family.

About have a family
to watch TV with.

Life's short, Brockett,
so short.

And I've waited
so long, too long.

James, you're really not
making any sense right now.

I want to go to a concert
with you, Brockett.

- What?
- I want to go out with you to a concert.

You know, like on a date.

- I get if I'm your boss...?
- No, it's not that.

I just, um... oh, I did...
I didn't know, James.

I... I didn't know.

And?

And, um...

I'm really sorry, James,

but I can't.

James.

Not now, W.

Just need a minute.

I'm attempting to write
a multi-modal imaging program

that merges three unique
computer languages

in the hopes of increasing
image clarity down to a tenth

of a millimeter to avoid
frying Giselle Overman's brain.

Does it sound like
I have a minute?

Well, when you do
have a minute...

Damn it!

- Keyboard!
- Okay.

I apologize.

That was very immature.

James?

Thank you.
Sorry for yelling.

I want to run some tests.
I'll need you to fast tonight.

We'll run some blood work
and I'll schedule an MRI, okay?

Okay.

We don't know anything yet, James.

We don't need to panic.

Debatable.

I can't believe
James did that. I mean,

the first-row tickets,
the backstage passes.

It's amazing.

So...

- Do you know who it is?
- Do I know who what is?

James kind of hinted that
there was someone he was into.

So, do you?

No, I don't.

Lucky girl.

Yeah, she is.

When did you start having
bleeding in your gums?

Uh, last night, when I
was brushing my teeth.

It's just a little
bit of spotting.

I haven't been to the
dentist in a while.

Start on 4.5 grams
of IV pip-tazo

every eight hours
and hang a unit

- of aphaeresis platelets.
- Yes, Dr. Brockett.

Is everything okay?

Yeah. Just want to be thorough.

She's pancytopenic.

The CAR T destroyed
a lot of the leukemia cells,

but it's also targeting
her healthy cell line.

With all this collateral damage,
she won't live long enough

for us to get her
into remission.

Maybe we refine
the antigen receptor.

It was the only target
we could find,

and it had
a lot of common antigens.

I can't make the key
any more specific.

If we keep going with these
treatments, we'll kill her.

What are the other options?

So, what, are we saying
Maddie's gonna die, that's it?

James, we all knew
this was a Hail Mary pass.

W, I need you.

It's happening, left hand
this time. Right here,

this spot.

- Describe what you're feeling.
- Tingling,

not as strong as last time.

Gone.

It's over.

I'm scared, W.

Yeah, I know.

- Okay, what's happening?
- I have no idea.

I do not accept that
this girl is gonna die here.

Not in our house.
There is no such thing

as a death sentence in
Bunker Hill, so... ideas,

pitches? Anything. Please.

We just don't have anything else
to offer at this point.

At this point? At this specific
moment in time, but maybe in a year,

maybe in six months or
maybe even a couple weeks

we might have something
better, right?

- No, a couple of weeks is not a reason...
- Am I correct?

Yes.

So what we need here
is to buy time

to find a cure that won't kill her.
How do we buy time?

James. Right now, she's at risk
for continued infection,

severe bleeding,

anemia that could effect
her organs and her heart.

If her white cells

- get high enough...
- Stop the negativity, please.

What can we do
to keep her alive?

I suppose we could cover her with a broad
spectrum of IV antibiotics... long term.

And if we put in
a central line, we can

continue with regular blood
and platelet transfusions.

We need to support her
anemia with oxygen.

And if she has any
respiratory distress,

we could intubate her and
put her on a ventilator.

Think of what you'd be doing
to her, putting her through.

- Think about her family.
- I'd be saving her life.

That's my brain?

We combined three scans
to create this image,

and we were able to locate
the source of your seizure.

Dorothy, we're not
in County anymore.

Unfortunately, your seizure
source is in your thalamus,

deep in the brain.
Close to the brain stem,

- near, uh, vital arteries.
- Meaning?

Meaning if we're even thinking
about going in there we need

- zero margin for error.
- So we set up

a real-time
interoperative imaging.

Now Dr. channarayapatra
can track electric impulses

in the brain in real time
during surgery.

Like a deadly game of Operation.

This surgery
isn't going to be easy,

but we think we can
get to it if we follow

a carefully planned route.

We do need you to understand,

um, there is a real possibility

you may not wake up
from this surgery.

I understand.
It is frightening.

I'm-I'm not upset
because I'm scared.

I'm moved.

I'm willing to take the risk.

I don't have kids.
I-i don't have a husband.

I have my clients.

And what good am I
if I can't help them?

Thank you.

Then, with your permission, we'd like
to schedule this for tomorrow morning.

Tomorrow morning.

Merry Christmas, huh?

- Let's do it.
- Let's do it.

I hope to hell this works.

Oh, you'll do great.
This will work.

Dr. Wallace.

This is the first time this kind
of surgery's ever been attempted.

I would be honored
if you would scrub in with me.

My wife just flew all the
way out here to see me.

Tomorrow's my only
day off, so...

Of course.
You guys have fun.

Yeah.

Bring this one home, Doctor.

We could all use a win
right now.

Your cells built up a resistance

to the CAR T cell therapy...

So there's no chance
of trying that again?

That strategy
is no longer viable.

We are meeting and talking

and doing everything we can

to try to find something
that will work for you.

What are you still doing here?

Um...

I'm gonna stay the night.

Maddie's numbers
don't look good.

I don't want to be far.

I hope your patients know
how hard you work for them,

Dr. Brockett.

You okay?

Yeah.

Hey.

What's going on?

I was just
thinking about my mom.

She had cancer.

Breast cancer.
Came back

three times,
it spread everywhere.

I was 14 when she died.

That's when I decided
to become a doctor.

Somehow Maddie has just

brought it all back to me...

How helpless it feels.

It's so unfair, Malik.

Yeah.

Sorry. This is
so embarrassing.

- I'm a doctor, patients die. I just...
- No, hey, hey, come here.

It's all right.

You okay?

- Mmm.
- Good?

- Wow, yeah.
- I hope not too dry.

- No, it's perfect.
- Oh, good.

Hardly done any cooking.
I've been working crazy hours.

Yeah. Um, that doctor...

Channaray...

- Channarayapatra.
- Yeah.

She mentioned that.

She's really talented.

Yeah. And a former Miss India.

I'm not kidding.

She really was Miss India.

For real.

She was?

According to Google.

Why would you Google her?

Oh, I don't know, Walt.
Why would I do that? She's only

a gorgeous and brilliant single
heterosexual that you're

sharing an office with
and you never mentioned her.

I never mentioned her because
there's nothing to mention.

Mm. I see.

Are you really upset by this?

I'm not upset
about her specifically, no.

- Well, you're upset about something.
- Okay, I'm upset.

Maybe I-I think I'm upset
because this started out

as a job that you had to take.
It was a stopgap measure

because of what happened
in Ohio,

because you couldn't
get a job anywhere else.

And suddenly you're working
all hours of the night

and your sharing an office
with-with

a brilliant and exotic
beauty queen.

- Jules...
- This is what I need to know:

If you are so happy here...

Where does that
leave our family?

Luke's going to college
in a couple of months...

No, us!
Where does it leave us?

It leaves us in love with each other
and working in different places.

- People make it work.
- Oh, all right.

So then you've decided
to stay. That's it.

- I have not decided to stay.
- Yes, you have, you have.

You just...
You don't know it yet.

Fine. I do like it here.

I like that Louis Keating
has a rare disease

that nobody cares about
and we're fighting for him.

I like that we don't
just throw up our hands

and say, "We give up".

And this isn't some new me,

this is the old me.
The young,

idealistic medical student that
you fell in love with, Jules.

And this is the man
who risked my job

to save that kid's life in Ohio.

What are you doing here?

I didn't want to wake you.

That's only slightly creepy.

I'm sorry.

How are you feeling?

They already
explained things to me, James.

I get it.

You tried.

And I love you for that.

We have a plan. I want to
keep you alive long enough

to find a way to make this work.

We came close.
We can do this.

What it will take
will be a little drastic.

And some discomfort.

You'll need regular blood transfusions
and possibly a feeding tube to help

- with nutrition...
- James, listen.

And I need you to really
listen to me, okay?

Okay.

I've waged my battle.

You helped me do that.

And I fought hard.

I fought really, really hard.

And I'm ready
for whatever comes.

I've made my peace.

Okay, James?

I don't know if I'm ready.

How's your plan going?

The one about watching TV
with a family.

Not... so great.

Hmm.

Okay. Well...

Maybe you need to stop thinking
about the big five-year plan

and just start thinking
one step ahead.

You know?

Like... go to a concert.

And an actual concert, not for some
band that broke up 1,000 years ago.

Go to a concert right now.

Live your life, James.

Hey.

Hi.

Hey.

Jules, um, can we just...
move past last night?

This is our only
day alone together.

Yeah, I want that, too.

Good. Well, if we leave
soon, we'll beat traffic

and be in San Francisco
in a half hour?

Uh, museums
open at 10:00.

Then the Golden Gate Park.

I was gonna have James call in a favor and
get us a table at Chez Panisse for lunch.

Or we can do something else.

You know, what I think
I'd really like to see

is, uh, Bunker Hill hospital.

Because I hear
they're performing

an amazing surgery there today.

Show me the miracle, Walt.

What about your day
with your wife?

She couldn't miss this.

Neither could I.

Those are
the thalamocortical radiations.

The key determinants
of consciousness.

If we know they're there,

we know how to avoid them.

I thought a lot about what I truly
want my first concert to be.

Part of me would go with the legends,
Paul McCartney, and the Stones.

Another part of me would just turn
up to a little club on the Haight,

just watch some guy
trying to make it.

And then I thought
it's probably less

about who you're seeing
and more about who you're with.

So I decided I want my first
concert to be with you.

Oh, my God.

Oh, my God.

Heather,
what are you doing here?

Aunt Meg, hi!

Hi, guys.
I love you guys.

How did all of this happen?

It was all James.
He sent a plane for everyone.

James?

♪ Hold on ♪

♪ to me as we go ♪

♪ As we roll down ♪

♪ this unfamiliar road ♪

♪ And although this wave ♪

♪ is stringing us along ♪

Come on, help me out.

♪ Just know you're not alone ♪

♪ 'cause I'm gonna make
this place your home ♪

♪ Settle down ♪

♪ it'll all be clear ♪

♪ Don't pay no mind
to the demons ♪

♪ they fill you with fear ♪

♪ The trouble,
it might drag you down ♪

♪ if you get lost ♪

♪ you can always be found ♪

♪ Just know you're not alone ♪

♪ 'cause I'm gonna make
this place your home ♪

♪ Now, ooh... ♪

♪ ooh... ♪

♪ ah-ooh... ♪

The study wasn't approved.

I won't stop fighting for you,
Louis.

Do you understand me?

I will not give up.

I'm fighting for you.

I'm fighting for me, too.

We're in this together, Louis.

I might be running out of time,
James.

My mouth's bleedin', Bert!

My mouth's bleed...
Zuzu's petals.

Zuzu... there they are!

Bert, what do you know
about that?!

What are you doing here?

I sent the team home.
It's Christmas Eve.

Your tests came back.

Your tremors aren't from GSS.

That kombucha you're drinking,
it's heavily caffeinated.

Your tremors were probably
a combination of sugar,

caffeine, and too little sleep.

You need to take care of yourself, okay?

How's Giselle Overman?

Eight hours, no seizures.

Already turned her recovery room
into a temporary office.

We did it, James.

See?

It is a wonderful life.

Yeah.

Merry Christmas, James.

Merry Christmas.

W?

Will you sit with me
for a few minutes?

Sure, James.

Merry Christmas!

Merry Christmas!

Merry Christmas!