Nova (1974–…): Season 47, Episode 5 - Cuba's Cancer Hope - full transcript
When the trade embargo left Cuba isolated from medical resources, Cuba was forced to get creative. Now they've developed lung cancer vaccines that show promise, some Americans are defying the embargo and traveling to Cuba for trea...
One in three Americans
will be diagnosed with cancer
in their lifetime.
I... I have cancer?
Like getting hit by a truck.
The PET scan showed that I had
eight metastasizes in the chest.
I become anxious
because their options
become more and more limited.
Some take matters
into their own hands.
You know, I'm not trying
to break the law.
But I'm also not gonna die.
Even if it's illegal
to get treatment
where they're going...
Cuba.
Wow...
In Cuba, jeez.
What could come out of Cuba
that we don't already know?
How did a small nation
cut off from modern
medical technology
become a world player
in cancer science?
Cuba was forced to think
outside the box.
Castro had a vision.
If there's a 2% chance
the science is right,
we need to be there.
And there's nothing
in the United States.
Can scientists whose countries
are political adversaries
now work together
to fight cancer?
If you are isolated,
you are dead in science.
Cooperation is everything.
Mosquito.
Yeah.
We added the Cuban vaccine,
and his cancer gets smaller,
and disappears.
"Cuba's Cancer Hope."
Don't cry.
Right now, on "NOVA."
Major funding for "NOVA"
is provided by the following:
Life isn't meant to be fair.
It's meant to be lived.
George Keays has always loved
the outdoors.
He's 67 years old.
I was very active...
Runner, swimmer,
loved mountain sports,
skiing, snowboarding,
and that kind of thing.
Today, he's preparing
for an unusual trip.
It's a matter of life or death.
George has stage IV lung cancer.
So this was really
kind of a shock.
Something like this put a crimp
in your style.
This isn't George's
first encounter
with the deadly disease.
My wife was diagnosed years ago
and my daughter was, uh, ten
and my other daughter was 20,
and then she passed away
when they were 14 and 24.
It was tragic;
they were, you know,
very, very close to their mom.
One in three Americans will have
cancer in their lifetime.
It's one of the leading causes
of death worldwide.
When I first received
the diagnosis
of stage IV pancreatic cancer,
I was like, "Huh?"
"I... I have cancer?
"Like, other people have cancer,
I don't have cancer...
What are you talking about?"
It was, uh, definitely
like getting hit by a truck...
Unexpected, for sure.
I said, "Did you just
drop the bombshell on me"
that I think you did?"
And I think that's when
it finally clicked.
And he said yes.
I'm about to be 35 in two weeks.
It's been two years
that I'm living with
metastatic breast cancer
at stage IV.
There are more than 100
different types of cancer.
In the U.S., they kill anestimated
600,000 people a year.
The havoc cancer wreaks
on patients and families
is devastating.
My mom passed
because of breast cancer,
and my dad passed
because of lung cancer.
So for me...
cancer was death.
There's a period between
Christmas and New Year's
one time where I didn't
get out of bed
for that entire...
entire period, you know?
My one daughter came in
and said, "Hey, Dad?"
You ever...
"Are you ever going to come play
with me again?"
You go from being very healthy,
suddenly, "Well, you have
six months to live."
It hit my daughters
very, very hard.
My oldest daughter said, um...
"I just love you so much."
When George was diagnosed,
he discovered patients like him,
where lung cancer metastasizes
throughout the body,
often don't live much longer
than a year.
That was four years ago.
George is convinced
what's helping him stay alive
is a new treatment
that goes beyond the radiation
- and chemo he's received.
- And chemo he's received.
It's actually a lung cancer
vaccine.
It's one of a new wave
of treatments
that are transforming some
cancers from a death sentence
into a chronic condition
likediabetes or high blood pressure.
We're really in
a scientific revolution,
particularly when it comes
to cancer research.
Because there are a number of
patients with deadly cancers,
we can turn them into
chronic diseases
where they're living years.
But the cancer vaccine
George is receiving
is not available in the U.S.
In fact, it's against the law
for him to go
where he's been goingfor
this cutting-edge treatment.
You know, I'm not trying
to break the law.
I'm not,
but I'm also not gonna die.
To fill his prescription,
George has to fly 2,000 miles...
to Cuba.
But why is George
risking a trip to Cuba,
when some of the most advanced
cancer medicine in the world
is back in the U.S.?
What could a small
communist nation
embargoed by the U.S.
for over 50 years
bring to the fight
against cancer?
Cuba's advances in cancer
treatment are largely unknown
to most Americans.
I think everybody here
thought that Cuba was stuck in
"I Love Lucy" days...
You know, the 1950s, old cars,
can't possibly be any good
science going on.
I mean certainly I did not know
about what was going on.
Kind of, you know,
what could come out of Cuba
that we don't already know?
Cuba is a small country
with big contradictions.
Even though the island
is impoverished,
it continues to provide
freehealthcare to all its citizens.
One of them is Marta Reymo.
She shares her small apartment
in Havana
- with her family, including her grandson.
- With her family, including her grandson.
Yes, yes, I smoked.
But, like a year before I got
the disease, I quit smoking.
Why?
Because I had a sister who had
the same thing I have today.
And when she had cancer
and the doctor talked about
smoking and such,
I quit too, but, well,
the damage was already done.
The popularity of Cuba's famous
cigars and cigarettes
contributes to lung cancerbeing
the deadliest cancer here,
as it is in the U.S.
Some time in 2009, Marta just
wasn't feeling like herself.
I went in for my X-ray
and an ultrasound
and I had a CT scan.
After all the tests,
they told me that I had a growth
in my right lung.
Like George Keays,
she was diagnosed with
inoperable stage IV lung cancer.
Saying that disease,
I thought the worst.
I thought I was going to die.
Not only did Marta lose
her sister to lung cancer,
but Marta's daughter...
Who is a nurse...
Lost her husband as well.
My husband died six months
before this,
from the same disease, and now
I have to face the situation
again with my mother.
It was really hard for me,
very difficult.
Marta's lung cancer began
the way all cancers do.
Cancer is
our own body going awry,
starting with a single cellin
our body that stops listening
to the signals to stop growing,
or stop behaving
in a certain way.
And when that cell stops
listening to those signals,
it starts growing
out of control,
and it turns into cancer.
The bloodstream becomes cancer's
highway to reach other organs.
And so then she says, um...
"You have it in multiple areas
of your body,
"it's already spread.
"It's in your ovary,
it's in your liver,
"it's in your pancreas,
and you got a couple areas
in your lungs."
One day when I was working,
I heard something,
like... breaking,
and they took me
to the emergency room,
took the pictures, and it shows
a fracture in my spine.
The cancer made that.
Historically in the fight
against cancer,
treatment options
have been surgery, radiation,
and chemotherapy.
Marta's found another option.
For ten years she's been taking
a cancer vaccine
called CIMAvax-EGF.
- Cuban clinical trials show that it extends life
- Cuban clinical trials show that it extends life
By three to five months
on average.
And about 15% of patients,
including Marta,
have survived five years
or more.
CIMAvax is one of a class
of new drugs
that activates the immune system
to fight cancer.
They're called immunotherapies.
Immunotherapy broadly
is essentially
using the immune system
to fight human disease.
Our immune system protects us
from infection and disease
by identifying foreign threats
like bacteria or viruses
that are dangerous to the body.
When a threat is identified,
immune cells,
like killer T-cells, aresignaled
to attack and destroy.
But it was only in the last
few decades that scientists
realized they could use
the immune system
to not only attack
foreign invaders,
but also attack cancer.
I feel that
after all these meds,
I have gotten my life back.
I've been getting treatment
for ten years now.
Marta's daughter works
the day shift as a nurse.
At night, she helps organize
her mother's care.
Most of the medicines
distributed to patients
like Marta are manufactured
in Cuba.
We have been able to extend
her life, and quality of life,
that's the most important thing.
The CIMAvax cancer vaccine
Marta's taking
is now used to treat
thousands of patients in Cuba
and other countries.
How is it possible for a country
as poor and isolated as Cuba
to come up with cutting-edge
medicines like this?
Cuba's unique approach
to medical research
stretches back 60 years...
To the time of the
Cuban Revolution.
1959.
Fidel Castro, a former lawyer,
leads a revolution thatoverthrows
the Cuban government.
The revolution establishes
a one-party Communist state
with Castro as its
authoritarian leader.
It was not only
a change of government.
It was mainly a change
of economic, political,
and social structure
of the country.
Medical science is at the heart
of Castro's vision.
He was a person who clearly
was obsessed with public health
and education.
In 1960,
year one of the revolution,
he talked about the need
for, for science in Cuba.
So from the very beginning,
he saw science as an opportunity
to bring Cuba
kicking and screaming
into the modern era.
He claimed on several occasions
that access to healthcare wasthe
most fundamental human right
that existed in the world.
Castro promises
free healthcare...
A promise later written into
the new constitution.
But as the new government
nationalizes business,
confiscates private wealth,
and tears lives apart,
many professionals...
Including doctors...
Flee the country.
If you were part of the white
urban middle class in Havana,
you had everything to lose
by staying.
Most of the doctors decided
that it was in
their best interest
to, to leave.
Juan Vela Valdés was minister
of higher education.
In 1958, we had 6,500 physicians
in our country.
From '59 to '62, in three years,
half of the doctors flew away
from our country.
Cuba has to rebuild
the healthcare system
from the ground up.
Castro establishes
new universities,
clinics, and medical schools
across the island.
And he sends thousands
of medical students
and doctors abroad
to study at some of
the top medical universities
in the developed world.
During the '60s and the '70s,
many people were sent abroad
to study science.
I spent two and a half years
in Paris.
Agustín Lage was later chosen
to be the first director
for the Center of Molecular
Immunology,
one of Cuba's leading
biopharma research centers.
Getting training
in biochemistry
and cancer biology,
my... my supervisor
is Luc Montagnier,
discoverer of the AIDS virus.
When they return to Cuba,
many of these students
and doctors
are tasked with building
the country's
new public health service...
The difficulty heightened
by political tensions
and economic isolation.
The forces of Communism
are not to be underestimated
in Cuba or anywhere else
in the world.
In 1962,
at the height of the Cold War,
President Kennedy announces
an expanded trade embargo
against Cuba.
Today, Cubans call it
"el bloqueo"... "the blockade."
The American embargo would
include hospital equipment,
medical supplies,
and even ordinary antibiotics.
As a result,
Cuba was forced
to think outside the box,
particularly in terms
of medical research.
One of the things that-that
allowed it to do
was to start producing
its own medicines.
Castro developsa
self-sustaining medical sector
to manufacture medicines
for Cuba's public health
service.
Throughout his regime,
Castro continues to emphasize
the importance of human capital
and science as Cuba's future.
Today, Cuba reports
health statistics
that rival the U.S.
But some researchers caution
these may be unreliable
due to manipulated data.
Free medical care
for ordinary Cubans
is provided often at clinics
with scarce equipment
or serviced by physicians who
drive cabs to make ends meet.
That's not the case
at La Pradera.
It was designed to attract
international patients
who pay in hard currency.
So we're going to turn... here.
For nearly two years,
George Keays has been coming
here for treatment and rest.
Everyone knows George.
My mother in Cuba.
I think it was March of 2015,
and I went for
an annual physical
with my primary care doctor.
He said at that time, "You know,
your cough looks kinda like"
maybe an allergic cough."
But the cough was getting worse
and so ordered a CAT scan.
And I remember I left the office
and the doctor called me.
"Get back in here.
You have a growth in your lung."
So, then I went for
a full-body PET scan
to determine how far
this had spread.
It showed that I hadeight
metastasizes in the chest
along the lymph nodes,
one in the shoulder and it
had spread to my brain,
so I had a brain tumor as well.
Lung cancer is the leading cause
of cancer deaths worldwide...
More than 1.6 million each year.
More than breast, colon,
and prostate cancers combined.
Here is a reconstructedCAT scan.
This is the metastasis.
One reason lung cancer
is so deadly,
is that often, by the time
there are symptoms...
Like coughing, back pain,
or difficulty breathing...
The disease has already spread.
The large tumor here...
This was distressing news
for George, a non-smoker.
His lung cancer cells had been
growing undetected for years.
At that point, you know, the
prognosis was pretty grim...
Less than two years,
probably less than a year.
Late-stage lung cancer
progresses very quickly.
Historically there hasn't really
been much to do other than
try chemotherapy, try radiation,
try some maybe targeted therapy,
and then
keep people comfortable...
until they die.
I had had 15 radiation
treatments
in the clinical trial program.
And one radiation treatment
to the brain.
I was taking gene therapy.
And then cancer mutates,
it basically
starts to get smart
about what you're...
what you're treating it with.
Watching the news one evening,
George learns about
new treatments emerging in Cuba.
A lung cancer vaccine,
developed in Cuba...
I actually saw it on television
where people from Roswell Cancer
Center in New York
went to Cuba,
and they were looking at
alternative treatments.
His research convinces him
the Cuban drugs
might help him more than
what is available in the U.S.
George wants in.
His doctor urges him
to call Havana.
And they said,"Yeah,
we think that, you know,
"you, you could...
you could come down here,
and see if a vaccine
might work."
Immunotherapies,
including Cuba's cancer
vaccines,
are a medical breakthrough.
For years, scientists believed
the immune system could not
attack cancer cells,
because unlike an invading
virus or bacteria,
they are considered to be
part of us.
Cancers are really 99% you.
They're 99% normal.
So the immune system
largely sees them as normal.
Even into the 1980s, researchers
who believe they can harness
the immune system against cancer
are considered renegades.
I was a graduate student
in the late '70s at Stanford.
People were suspicious
of the ability to actually
provoke an immune response
against the cancer cells.
We're saying we can do something
against cancer,
and everybody's sort of
laughing, right.
But it turns out theimmune
system does fight cancer.
The battle begins as soon
as normal cells
mutate into cancer cells.
Long before anybody knows
that they have cancer,
there's this ongoing war
of the immune system
trying to control the cancerand
the cancer trying to escape.
If the cancer learns how to mask
itself from the immune system,
it can gain the upper hand
and grow.
So by the time the cancer
actually grows large enough
to be detected
by our normal tests,
it's already figured out how toget
away from the immune system.
But finally, researchers learned
how cancer masks itself.
And in 2018, Tasuku Honjo
and James Allison
won the Nobel Prize
for discovering
how to unmask cancer
and let the immune system
do its job.
This is how it works.
When you and I get
an infection...
usually the immune system
revs up.
But at some point,
the immune system
has to stop and rest.
The body has natural mechanisms
that stop the immune system
so it won't damage
ordinary cells.
These are called checkpoints.
But, it turns out
that these same mechanisms
that tells the immune system
to stop
have been hijacked in cancer.
The cancer is sending a signal
to the immune system to stop.
Honjo and Allison figured out
how to turn the immune system
back on.
Their discoveries led
to checkpoint inhibitors...
Drugs that can turn
cancer's signal off.
Now, the immune system
canrecognize the cancer and attack.
It took 30 years ofunderstanding
the immune system
before we could understand
how to make the immune system
recognize cancer.
How did scientists learn
to use the immune system
as a weapon against cancer?
For Cuba,
and the rest of the world,
it all starts with interferon.
A substance known
as interferon...
the body produces interferon
in minute amounts.
The body's natural
first line of defense
against viral infection.
In the 1980s, interferon
was a science sensation...
The first breakthrough drug
madefrom the body's own immune cells
with the potential
to fight cancer.
Interferon is a major defense
mechanism the body uses
when it is infected with a virus
or has a cancer growing in it.
Interferon can prevent
viral infection from spreading
and signals immune cells
to attack the virus.
- Interferon was our very first immunotherapeutic drug
- Interferon was our very first immunotherapeutic drug
That could be made
in large quantities.
In 1980,
renowned American oncologist
Randolph Lee Clark visits Cuba
and tells Castro
about interferon.
Dr. Clark explained to Fidel
that interferon was
one of the promising drugs
for cancer treatment.
That's what drove him
to want to make interferon.
Castro sends doctors first
to study with Clark in Texas
and then to Helsinki, Finland,
where they learn
how to purify interferon
from white blood cells.
When they return to Havana,
the doctors are taken
straight to a house
refitted with
a new laboratory...
House 149.
Castro gives them
a simple instruction:
make interferon for Cuba.
They worked constantly every day
until 10:00 or 11:00 at night.
Fidel came here
almost every day,
just making questions.
It was very, very,
very intensive.
It takes scientists
in other countries
as long as a year to replicate
the purification process.
The Cuban doctors
master it in 42 days.
But around the same time,
a new technology,
first developed in California,
is gaining ground worldwide:
genetic engineering.
Castro sends Luis Herrera
to Europe to investigate.
I remained in Europe some time
getting that information.
I came back, and I met Fidel.
And then he started
to make questions
concerning genetic engineering.
The genetic engineering process
Herrera brings back to Cuba
is transforming science
across the globe.
In the laboratory, scientists
remove a section of DNA
from a human cell
that codes for
a specific protein.
They then insert that DNA into
the DNA of a bacterial cell.
As the bacteria replicates,
it carries the code for the
human protein in its own DNA.
And you can put the bacteria
in a fermenter,
and you have millions
of flasks of interferon.
It turned out interferon only
works against a few cancers.
But the process
of making interferon
- took immunotherapy science to a new level.
- Took immunotherapy science to a new level.
Genetic engineering
started a new approach
to fighting cancer
around the world and in Cuba.
By this time,
Castro's ambitions were clear.
That's the first time
I heard him to say
that we can become
a medical power.
That was the beginning
of the whole biotechnology
development in Cuba.
Cuba would go on to build a
world-class biotech industry.
Research, development,
quality control,
and distribution
are all the responsibility
of one government agency:
BioCubaFarma.
They're a small country,
the communication is much
quicker and faster.
They can, um, immediately
make a drug available
to all the patients
who qualify for that drug
and immediately collect the data
on a large number of patients.
Cuba's 30-plus
bio-pharma facilities
hold over 2,000
international patents
for drugs and processes
in use around the world.
But the trade embargo
makes all these treatments
unavailable in the U.S.
Like Vaxira, the cancer vaccine
George Keays has been taking
for nearly two years.
I get one to two calls a week
from people
who have heard about me,
have heard that I'm coming here,
and ask questions, like,
"Where do you get the vaccine?
How did it work for you?"
You know?
I think there are some people
for whom this might not work,
but I think
there are a lot of people
for whom this can be beneficial.
But now American patients
could be on their way
to having access toCuban
cancer treatments legally.
And it all started
with a cold call
to Roswell Park
Comprehensive Cancer Center
in Buffalo, New York.
I was sitting in my office,
and my secretary came
to me and said,
"There's a telephone call
for you
from someone who is from Cuba."
When I picked up the phone,
what she talked about
was the fact that
they have some innovative
approaches in Cuba
that she would like
to discuss with Roswell Park.
I have to tell you, myinitial
response was skeptical.
So, my first question is,
"Why are you talking to us?"
And she talked
about the fact that
this is one of
the few institutions
in the United States
where the discoveries in Cuba
could be taken to the next level
and make sure it benefits
a wide range of patients,
not only in Cuba
but across the world.
Eventually, the researcher
from Cuba's Center
of Molecular Immunology,
or C.I.M.,
is invited to make
a presentation
on the lung cancer vaccine
CIMAvax-EGF,
the same vaccine that
Marta Reymo has been taking.
It is a standing room only
event.
Well, I think, scientists,
we're all a little crazy.
And so we all...
we all want to, uh,
hear something
really interesting.
It sparked curiosity
of how it came to be.
And so, that was what
I recall from it, is, "Wow."
In Cuba, jeez."
Cancer vaccines are already in
development around the world,
but what surprises
Roswell Park researchers is
the science that
makes this vaccine work.
They had thrown out
the first chapter
of any basic immunology textbook
to actually accomplish
the science.
Cuban scientists claim to
havefound a new way to fight cancer
by first getting
the immune system
to do something
it's never supposed to do:
attack a healthy human protein.
The research Cuba presents
atRoswell Park goes back to 1981.
A young scientist
named Rolando Pérez
is investigatingepidermal
growth factor, or EGF.
It's a natural protein
in the body
that tells cells to multiply.
Pérez is one of many
scientists around the world
trying to understand the role
EGF might play in cancer.
We wanted to know
whether human breast tumors
were dependent on EGF
for their growth.
What we found was ahigh
expression of EGF receptors
in about 50% of tumors.
A receptor is a protein molecule
on the cell's outer surface.
When an EGF protein connects
with an EGF receptor
on the cell's surface,
the protein sends a signal
to grow and multiply.
It was really a surprise
to find that there were tumors
which had a high dependence
on EGF.
At Roswell Park,
researchers show
how live cancer cells
use EGF to grow into the
beginnings of a tumor mass.
In the culture that has
epidermal growth factor,
you can see a layer
of lung cancer cells
that over time are
dividing and growing
and getting bigger and bigger.
In the culture that
has the lung cancer cells
but has been depleted of EGF,
you can see that
the lung cancer cells
have in fact stopped growing.
Pérez's research points out
some tumor cells have
thousands more EGF receptors
than healthy cells.
To prevent cancer
from using EGF to grow,
the Cubans came up
with a novel idea:
starve the tumor by removing EGF
from the equation.
To do this, they would have to
vaccinate the body against EGF
and convince the immune system
this normal human protein
is a threat.
But it wouldn't be easy.
If you vaccinate a human being
with human EGF,
nothing happens,
because the immune system
interprets that this is self.
A typical vaccine
includes a weakened dose
of the virus or bacteria
being targeted.
Once it's injected
into the body,
the immune system
produces antibodies
that attach to the invader
and attract other immune cells
to destroy it.
Memory cells remember it
in case it comes back again.
To get the body to recognize EGF
as a threat,
Cuban scientists attached
a protein
from the meningitis bacteria
to the EGF protein.
So, then the invention was
to link human EGF
with a protein that is coming
from a bacteria,
from the meningitis bacteria,
by the way.
And as the bacteria protein
is there,
then the immune system
interpret,
"This is non-self
and dangerous."
The attached bacterial molecule
causes the immune system
to see all EGF as a threat.
Antibodies signal immune cells
to eliminate the EGF.
The idea is to starve
lung cancer cells
of something
they depend on to multiply
but leave enough EGF in the
bodyfor ordinary cells to function.
As it turns out,
CIMAvax is most effective
for lung cancer patients
like Marta,
who already have high levels
of EGF in their blood.
You are making a trick
to the immune system, no?
You trick the immune system,
because you present something
self as if it were non-self.
When Roswell Park researchers
learn the science
behind CIMAvax,
many are convinced
it could be a game-changer.
They urge president and C.E.O.
Candace Johnson
To consider the possibility
of a partnership.
It was really
a couple of individuals
that decided
to really press this.
"And let's,
let's see what we can do.
"Let's reach out to these folks
in Havana
and see if we can establish
somesort of relationship with them."
Then, in 2014...
Good afternoon.
History opens a door.
Today, the United States
of America
is changing its relationship
with the people of Cuba.
President Obama
beginsnormalizing relations with Cuba.
And New York Governor
Andrew Cuomo
leads a trade delegation
to Havana.
So, the governor wanted
to take a group of leaders
from around the state,
and he chose me.
I could bring one person,
and I took Dr. Lee.
So here we all go into Cuba,
we're only there for 36 hours.
And Dr. Lee and I decided
that this was an opportunity
to really do this.
Roswell Park scientists believe
Cuba's CIMAvax could add
to the arsenal of weapons
available for cancer patients.
The Cubans hope for access
toresearch data from Roswell Park
and even technologies that
couldimprove their immunology drugs.
We have limited resources,
because of... we are
in a poor country.
We have also limited resources,
because the best and
the most efficient technology
are usually coming
from the U.S.,
and we don't have
access to that.
One example is this
American-made flow cytometer.
It suspends samples in a fluid
and whisks them
through multiple lasers,
one cell at a time.
Tens of thousands
of cells' characteristics
are rapidly analyzed.
In the U.S.,
the device is standard
for advanced research
and clinical trials.
So, in this case,
we're measuring the T-cells
in the patient's blood
in order to determine what
type of T-cells are present.
One department at Roswell Park
has over 20
of these expensive machines.
The data they could yield
for Cuban research
would be invaluable.
There are only two
such devices at C.I.M.
One is broken.
So, we had this equipment
broke for one year,
because we had to send
the equipment to Germany.
If this equipment has
more than ten percent
of the American component,
we can't buy.
Despite these limitations,
Cuban science makes
important strides,
even as American discoveries
in immunology treatment
continue to lead the world.
For Roswell Park,
a partnership with Cuba
could allow them to combine
C.I.M.'s cancer vaccine
with immunotherapy treatments
already available,
like checkpoint inhibitors.
- What we're realizing now is that
- What we're realizing now is that
You have to combine
immunotherapy agents.
So, we're seeing studies
that are testing vaccine
with immune checkpoint agents.
At Johns Hopkins Kimmel Cancer
Center in Baltimore,
Bruce Toma is being treated
for stage IV pancreatic cancer.
One more.
He's participating
in a clinical trial
combining checkpoint inhibitors
with a cancer vaccine developed
by Dr. Elizabeth Jaffee.
This is how goodyour work has done.
Nobody can believe...
It's, it's so exciting.
That I'm stage IVmetastasized
pancreatic cancer.
I don't know how much
of your scans you've seen.
First one. The first one.
So what we're reallyexcited about
is that you had
all of this tumor here
at the peritoneum.
Mm-hmm.
Your most recent scan,
there's nothing there.
We can't detect it.
It's totally gone.
Oh wow, yes,
I can see the difference.
Immunotherapies are
incredibly expensive.
And not everyone has
the same success as Bruce.
And we don't know why.
If we can understand
why certain patients do benefit
from immunotherapy
while others don't benefit
from treatment,
we can make great leaps forward
in our cancer treatment.
Anything else going on?
Any headaches...
But for now, many patients...
No matter what therapies
they are receiving...
Will likely reach a point
when they run out
of treatment options.
As their cancer grows,
and the treatment
that I'm giving them fails,
I become anxious,
because with every step,
their options become
more and more limited.
Mum, she took the scissors,
and she started just
chopping off her own hair.
I'll never forget it.
My sister and I just stood there
just awestruck.
It was a very
emotional experience.
And Kathy was willing
to try anything.
And it was tough on her
when they, when they said,
"That's it,
there-there is no more,
and treatment would
only make you worse."
But Kathy held the doctor's hand
and said, "I understand."
They say usually
it's three years, the time.
I'm exactly at third year.
The doctor said
I have one more year to live.
It's no pain,
because the needle is so thin.
No, I see, mm-hmm.
Mosquito.
Yeah.
At La Pradera,
oncologists administer
George's Vaxira prescription.
Okay.
George's doctor and close friend
Dr. William Blanchet is
in Havana to lend support.
The cancer was growing,
the cancer markers were
getting bigger on this agent.
His oncologist
increased the dosage;
the cancer continued
to get bigger.
We added the Vaxira,
and his cancer gets smaller.
And so, on the
three-year anniversary
of being diagnosed with horrible
stage IV lung cancer,
this guy runs a ten-K run and
puts an offer down on a house.
Those are things that people
three years into stage IV
lung cancer tend not to do.
But George is not cured.
Cancer continues to be
a daily struggle.
In addition to Vaxira,
he's undergoing a number
of treatments in the U.S.
Despite this, his doctors
recently discovered
a new metastasis in his liver.
It's a hell of a thing
to have to take a risk
with, you know,
your-your wellbeing
that you...
that somebody could say,
"Well, you're breaking the law."
But could Cuban drugs
like Vaxira
become available in the U.S.?
In science, cooperation
is everything.
So if you are isolated,
you are dead in science.
Our legal department saying,
"How are we going to do this?
Is this going to be worth it?"
And I said, "If there's
a two-percent chance"
that the science is right,
we need to be there."
Cuba and Roswell Park come
to an agreement to cooperate.
In 2016, CIMAvax becomes
the first Cuban drug ever
approved by the FDA
for clinical trial in the U.S.
At Roswell Park,
it's being combined with
acheckpoint inhibitor, nivolumab,
that could make CIMAvax
even more effective.
And the flip side is
the way CIMAvax works,
it may make nivolumab
work better as well.
Think of it like, can
one plus one equal to five?
So that's the ultimate
goal of testing.
Two years later, Cuba's Center
of Molecular Immunology
and Roswell Park double down
on their partnership
and make history again.
The president and
C.E.O. of Roswell Park
announced the first-ever
biotech joint venture
between the United States
and Cuba.
We did it!
The two agree to build
a new biotech facility in Cuba
dedicated to cancer drugs,
jointly owned by
Roswell Park and C.I.M.
Eventually, we will
build factories.
And at some point of time
we will reachthe medical community
in Cuba and the U.S.
with new medicinesfor the people.
The embargo will continue to be
one of the biggest challenges
for the Roswell Park-C.I.M.
research partnership.
Even after the FDA approved
clinical trials in 2016,
Roswell Park worried the
embargowould make it almost impossible
to ship CIMAvax safely
from Havana to Buffalo.
So they tried
a test run with water
in a temperature-controlled box.
It actually got from
Havana to Canadian customs;
and the FDA was expecting it,
because we told them there
it would come.
Got to U.S. customs.
Apparently, if you're
on the embargo list
in the United States,
your country is not
in the electronic database.
So, the box went back to Canada
and sat there
for, I think, two days.
So the box is good for holding
temperature for 72 hours.
Nearly 200 hours after
being packaged in Cuba,
the box arrived in Buffalo.
The real vaccine
would have been destroyed.
These kinds of challenges
are critical to overcome
for the research partnership
to succeed.
Both sides are convinced
it's worth it.
Let's come tobrain tumors,
where the data thatwe have is pretty good.
Then there is nothing
in the United States...
It's a precedent-setting event.
You know, these are
American scientists
working so closely
with Cuban scientists.
They are presenting us
with very novel drugs.
CIMAvax has the potential
to work as a vaccine
to prevent
lung-cancer formation,
and that has a substantial
public-health implication.
I hope, I really hope,
that this won't be stopped
because this is
cancer treatment,
and these are American citizens
being treated
by cancer vaccines manufactured
here in this small country.
Even as political tensions rise
between their two countries,
Cuban and American scientists
continue on
in the hopes of
improving cancer treatment
and one day finding a cure.
If we work together
to raise the quality of the life
of our peoples,
that will bring us together.
Science is going to move
relationships forward.
The promise of lifting
theburden of cancer in all peoples
is going to move
the relationship forward.
I'm handling it,
and I want to keep going
because I have things
that I want to do,
I have things I want to see.
I have things I want to...
complete with my children.
I'm so lucky that I see things,
that I feel things on my skin,
and I don't want to lose it.
I want to live
my life the fullest.
If I can't walk,
I'll be on my knees.
If I can't be on my knees, I'll crawl.
But I'll continually
try to get back up.
And that will be my life.
How do you feel today?
Very good, very good.
Very good?
No pain.
Okay.
No pain.
Before going home,
George meets once more
with Dr. Anabely Garcia,
chief of his
Havana medical team.
And, here, we put in
the date that you receive.
You have vaccines
until August, okay?
Yes, that's right. We wait
for you next May or June.
Oh, no, no, no, no, no.
Don't cry.
Thank you.
I'll see you again in May.
Yes, of course.
Hasta luego.
One of the things you learn
is to live in the moment.
I may not be here in six months,
I-I don't know.
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will be diagnosed with cancer
in their lifetime.
I... I have cancer?
Like getting hit by a truck.
The PET scan showed that I had
eight metastasizes in the chest.
I become anxious
because their options
become more and more limited.
Some take matters
into their own hands.
You know, I'm not trying
to break the law.
But I'm also not gonna die.
Even if it's illegal
to get treatment
where they're going...
Cuba.
Wow...
In Cuba, jeez.
What could come out of Cuba
that we don't already know?
How did a small nation
cut off from modern
medical technology
become a world player
in cancer science?
Cuba was forced to think
outside the box.
Castro had a vision.
If there's a 2% chance
the science is right,
we need to be there.
And there's nothing
in the United States.
Can scientists whose countries
are political adversaries
now work together
to fight cancer?
If you are isolated,
you are dead in science.
Cooperation is everything.
Mosquito.
Yeah.
We added the Cuban vaccine,
and his cancer gets smaller,
and disappears.
"Cuba's Cancer Hope."
Don't cry.
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Major funding for "NOVA"
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Life isn't meant to be fair.
It's meant to be lived.
George Keays has always loved
the outdoors.
He's 67 years old.
I was very active...
Runner, swimmer,
loved mountain sports,
skiing, snowboarding,
and that kind of thing.
Today, he's preparing
for an unusual trip.
It's a matter of life or death.
George has stage IV lung cancer.
So this was really
kind of a shock.
Something like this put a crimp
in your style.
This isn't George's
first encounter
with the deadly disease.
My wife was diagnosed years ago
and my daughter was, uh, ten
and my other daughter was 20,
and then she passed away
when they were 14 and 24.
It was tragic;
they were, you know,
very, very close to their mom.
One in three Americans will have
cancer in their lifetime.
It's one of the leading causes
of death worldwide.
When I first received
the diagnosis
of stage IV pancreatic cancer,
I was like, "Huh?"
"I... I have cancer?
"Like, other people have cancer,
I don't have cancer...
What are you talking about?"
It was, uh, definitely
like getting hit by a truck...
Unexpected, for sure.
I said, "Did you just
drop the bombshell on me"
that I think you did?"
And I think that's when
it finally clicked.
And he said yes.
I'm about to be 35 in two weeks.
It's been two years
that I'm living with
metastatic breast cancer
at stage IV.
There are more than 100
different types of cancer.
In the U.S., they kill anestimated
600,000 people a year.
The havoc cancer wreaks
on patients and families
is devastating.
My mom passed
because of breast cancer,
and my dad passed
because of lung cancer.
So for me...
cancer was death.
There's a period between
Christmas and New Year's
one time where I didn't
get out of bed
for that entire...
entire period, you know?
My one daughter came in
and said, "Hey, Dad?"
You ever...
"Are you ever going to come play
with me again?"
You go from being very healthy,
suddenly, "Well, you have
six months to live."
It hit my daughters
very, very hard.
My oldest daughter said, um...
"I just love you so much."
When George was diagnosed,
he discovered patients like him,
where lung cancer metastasizes
throughout the body,
often don't live much longer
than a year.
That was four years ago.
George is convinced
what's helping him stay alive
is a new treatment
that goes beyond the radiation
- and chemo he's received.
- And chemo he's received.
It's actually a lung cancer
vaccine.
It's one of a new wave
of treatments
that are transforming some
cancers from a death sentence
into a chronic condition
likediabetes or high blood pressure.
We're really in
a scientific revolution,
particularly when it comes
to cancer research.
Because there are a number of
patients with deadly cancers,
we can turn them into
chronic diseases
where they're living years.
But the cancer vaccine
George is receiving
is not available in the U.S.
In fact, it's against the law
for him to go
where he's been goingfor
this cutting-edge treatment.
You know, I'm not trying
to break the law.
I'm not,
but I'm also not gonna die.
To fill his prescription,
George has to fly 2,000 miles...
to Cuba.
But why is George
risking a trip to Cuba,
when some of the most advanced
cancer medicine in the world
is back in the U.S.?
What could a small
communist nation
embargoed by the U.S.
for over 50 years
bring to the fight
against cancer?
Cuba's advances in cancer
treatment are largely unknown
to most Americans.
I think everybody here
thought that Cuba was stuck in
"I Love Lucy" days...
You know, the 1950s, old cars,
can't possibly be any good
science going on.
I mean certainly I did not know
about what was going on.
Kind of, you know,
what could come out of Cuba
that we don't already know?
Cuba is a small country
with big contradictions.
Even though the island
is impoverished,
it continues to provide
freehealthcare to all its citizens.
One of them is Marta Reymo.
She shares her small apartment
in Havana
- with her family, including her grandson.
- With her family, including her grandson.
Yes, yes, I smoked.
But, like a year before I got
the disease, I quit smoking.
Why?
Because I had a sister who had
the same thing I have today.
And when she had cancer
and the doctor talked about
smoking and such,
I quit too, but, well,
the damage was already done.
The popularity of Cuba's famous
cigars and cigarettes
contributes to lung cancerbeing
the deadliest cancer here,
as it is in the U.S.
Some time in 2009, Marta just
wasn't feeling like herself.
I went in for my X-ray
and an ultrasound
and I had a CT scan.
After all the tests,
they told me that I had a growth
in my right lung.
Like George Keays,
she was diagnosed with
inoperable stage IV lung cancer.
Saying that disease,
I thought the worst.
I thought I was going to die.
Not only did Marta lose
her sister to lung cancer,
but Marta's daughter...
Who is a nurse...
Lost her husband as well.
My husband died six months
before this,
from the same disease, and now
I have to face the situation
again with my mother.
It was really hard for me,
very difficult.
Marta's lung cancer began
the way all cancers do.
Cancer is
our own body going awry,
starting with a single cellin
our body that stops listening
to the signals to stop growing,
or stop behaving
in a certain way.
And when that cell stops
listening to those signals,
it starts growing
out of control,
and it turns into cancer.
The bloodstream becomes cancer's
highway to reach other organs.
And so then she says, um...
"You have it in multiple areas
of your body,
"it's already spread.
"It's in your ovary,
it's in your liver,
"it's in your pancreas,
and you got a couple areas
in your lungs."
One day when I was working,
I heard something,
like... breaking,
and they took me
to the emergency room,
took the pictures, and it shows
a fracture in my spine.
The cancer made that.
Historically in the fight
against cancer,
treatment options
have been surgery, radiation,
and chemotherapy.
Marta's found another option.
For ten years she's been taking
a cancer vaccine
called CIMAvax-EGF.
- Cuban clinical trials show that it extends life
- Cuban clinical trials show that it extends life
By three to five months
on average.
And about 15% of patients,
including Marta,
have survived five years
or more.
CIMAvax is one of a class
of new drugs
that activates the immune system
to fight cancer.
They're called immunotherapies.
Immunotherapy broadly
is essentially
using the immune system
to fight human disease.
Our immune system protects us
from infection and disease
by identifying foreign threats
like bacteria or viruses
that are dangerous to the body.
When a threat is identified,
immune cells,
like killer T-cells, aresignaled
to attack and destroy.
But it was only in the last
few decades that scientists
realized they could use
the immune system
to not only attack
foreign invaders,
but also attack cancer.
I feel that
after all these meds,
I have gotten my life back.
I've been getting treatment
for ten years now.
Marta's daughter works
the day shift as a nurse.
At night, she helps organize
her mother's care.
Most of the medicines
distributed to patients
like Marta are manufactured
in Cuba.
We have been able to extend
her life, and quality of life,
that's the most important thing.
The CIMAvax cancer vaccine
Marta's taking
is now used to treat
thousands of patients in Cuba
and other countries.
How is it possible for a country
as poor and isolated as Cuba
to come up with cutting-edge
medicines like this?
Cuba's unique approach
to medical research
stretches back 60 years...
To the time of the
Cuban Revolution.
1959.
Fidel Castro, a former lawyer,
leads a revolution thatoverthrows
the Cuban government.
The revolution establishes
a one-party Communist state
with Castro as its
authoritarian leader.
It was not only
a change of government.
It was mainly a change
of economic, political,
and social structure
of the country.
Medical science is at the heart
of Castro's vision.
He was a person who clearly
was obsessed with public health
and education.
In 1960,
year one of the revolution,
he talked about the need
for, for science in Cuba.
So from the very beginning,
he saw science as an opportunity
to bring Cuba
kicking and screaming
into the modern era.
He claimed on several occasions
that access to healthcare wasthe
most fundamental human right
that existed in the world.
Castro promises
free healthcare...
A promise later written into
the new constitution.
But as the new government
nationalizes business,
confiscates private wealth,
and tears lives apart,
many professionals...
Including doctors...
Flee the country.
If you were part of the white
urban middle class in Havana,
you had everything to lose
by staying.
Most of the doctors decided
that it was in
their best interest
to, to leave.
Juan Vela Valdés was minister
of higher education.
In 1958, we had 6,500 physicians
in our country.
From '59 to '62, in three years,
half of the doctors flew away
from our country.
Cuba has to rebuild
the healthcare system
from the ground up.
Castro establishes
new universities,
clinics, and medical schools
across the island.
And he sends thousands
of medical students
and doctors abroad
to study at some of
the top medical universities
in the developed world.
During the '60s and the '70s,
many people were sent abroad
to study science.
I spent two and a half years
in Paris.
Agustín Lage was later chosen
to be the first director
for the Center of Molecular
Immunology,
one of Cuba's leading
biopharma research centers.
Getting training
in biochemistry
and cancer biology,
my... my supervisor
is Luc Montagnier,
discoverer of the AIDS virus.
When they return to Cuba,
many of these students
and doctors
are tasked with building
the country's
new public health service...
The difficulty heightened
by political tensions
and economic isolation.
The forces of Communism
are not to be underestimated
in Cuba or anywhere else
in the world.
In 1962,
at the height of the Cold War,
President Kennedy announces
an expanded trade embargo
against Cuba.
Today, Cubans call it
"el bloqueo"... "the blockade."
The American embargo would
include hospital equipment,
medical supplies,
and even ordinary antibiotics.
As a result,
Cuba was forced
to think outside the box,
particularly in terms
of medical research.
One of the things that-that
allowed it to do
was to start producing
its own medicines.
Castro developsa
self-sustaining medical sector
to manufacture medicines
for Cuba's public health
service.
Throughout his regime,
Castro continues to emphasize
the importance of human capital
and science as Cuba's future.
Today, Cuba reports
health statistics
that rival the U.S.
But some researchers caution
these may be unreliable
due to manipulated data.
Free medical care
for ordinary Cubans
is provided often at clinics
with scarce equipment
or serviced by physicians who
drive cabs to make ends meet.
That's not the case
at La Pradera.
It was designed to attract
international patients
who pay in hard currency.
So we're going to turn... here.
For nearly two years,
George Keays has been coming
here for treatment and rest.
Everyone knows George.
My mother in Cuba.
I think it was March of 2015,
and I went for
an annual physical
with my primary care doctor.
He said at that time, "You know,
your cough looks kinda like"
maybe an allergic cough."
But the cough was getting worse
and so ordered a CAT scan.
And I remember I left the office
and the doctor called me.
"Get back in here.
You have a growth in your lung."
So, then I went for
a full-body PET scan
to determine how far
this had spread.
It showed that I hadeight
metastasizes in the chest
along the lymph nodes,
one in the shoulder and it
had spread to my brain,
so I had a brain tumor as well.
Lung cancer is the leading cause
of cancer deaths worldwide...
More than 1.6 million each year.
More than breast, colon,
and prostate cancers combined.
Here is a reconstructedCAT scan.
This is the metastasis.
One reason lung cancer
is so deadly,
is that often, by the time
there are symptoms...
Like coughing, back pain,
or difficulty breathing...
The disease has already spread.
The large tumor here...
This was distressing news
for George, a non-smoker.
His lung cancer cells had been
growing undetected for years.
At that point, you know, the
prognosis was pretty grim...
Less than two years,
probably less than a year.
Late-stage lung cancer
progresses very quickly.
Historically there hasn't really
been much to do other than
try chemotherapy, try radiation,
try some maybe targeted therapy,
and then
keep people comfortable...
until they die.
I had had 15 radiation
treatments
in the clinical trial program.
And one radiation treatment
to the brain.
I was taking gene therapy.
And then cancer mutates,
it basically
starts to get smart
about what you're...
what you're treating it with.
Watching the news one evening,
George learns about
new treatments emerging in Cuba.
A lung cancer vaccine,
developed in Cuba...
I actually saw it on television
where people from Roswell Cancer
Center in New York
went to Cuba,
and they were looking at
alternative treatments.
His research convinces him
the Cuban drugs
might help him more than
what is available in the U.S.
George wants in.
His doctor urges him
to call Havana.
And they said,"Yeah,
we think that, you know,
"you, you could...
you could come down here,
and see if a vaccine
might work."
Immunotherapies,
including Cuba's cancer
vaccines,
are a medical breakthrough.
For years, scientists believed
the immune system could not
attack cancer cells,
because unlike an invading
virus or bacteria,
they are considered to be
part of us.
Cancers are really 99% you.
They're 99% normal.
So the immune system
largely sees them as normal.
Even into the 1980s, researchers
who believe they can harness
the immune system against cancer
are considered renegades.
I was a graduate student
in the late '70s at Stanford.
People were suspicious
of the ability to actually
provoke an immune response
against the cancer cells.
We're saying we can do something
against cancer,
and everybody's sort of
laughing, right.
But it turns out theimmune
system does fight cancer.
The battle begins as soon
as normal cells
mutate into cancer cells.
Long before anybody knows
that they have cancer,
there's this ongoing war
of the immune system
trying to control the cancerand
the cancer trying to escape.
If the cancer learns how to mask
itself from the immune system,
it can gain the upper hand
and grow.
So by the time the cancer
actually grows large enough
to be detected
by our normal tests,
it's already figured out how toget
away from the immune system.
But finally, researchers learned
how cancer masks itself.
And in 2018, Tasuku Honjo
and James Allison
won the Nobel Prize
for discovering
how to unmask cancer
and let the immune system
do its job.
This is how it works.
When you and I get
an infection...
usually the immune system
revs up.
But at some point,
the immune system
has to stop and rest.
The body has natural mechanisms
that stop the immune system
so it won't damage
ordinary cells.
These are called checkpoints.
But, it turns out
that these same mechanisms
that tells the immune system
to stop
have been hijacked in cancer.
The cancer is sending a signal
to the immune system to stop.
Honjo and Allison figured out
how to turn the immune system
back on.
Their discoveries led
to checkpoint inhibitors...
Drugs that can turn
cancer's signal off.
Now, the immune system
canrecognize the cancer and attack.
It took 30 years ofunderstanding
the immune system
before we could understand
how to make the immune system
recognize cancer.
How did scientists learn
to use the immune system
as a weapon against cancer?
For Cuba,
and the rest of the world,
it all starts with interferon.
A substance known
as interferon...
the body produces interferon
in minute amounts.
The body's natural
first line of defense
against viral infection.
In the 1980s, interferon
was a science sensation...
The first breakthrough drug
madefrom the body's own immune cells
with the potential
to fight cancer.
Interferon is a major defense
mechanism the body uses
when it is infected with a virus
or has a cancer growing in it.
Interferon can prevent
viral infection from spreading
and signals immune cells
to attack the virus.
- Interferon was our very first immunotherapeutic drug
- Interferon was our very first immunotherapeutic drug
That could be made
in large quantities.
In 1980,
renowned American oncologist
Randolph Lee Clark visits Cuba
and tells Castro
about interferon.
Dr. Clark explained to Fidel
that interferon was
one of the promising drugs
for cancer treatment.
That's what drove him
to want to make interferon.
Castro sends doctors first
to study with Clark in Texas
and then to Helsinki, Finland,
where they learn
how to purify interferon
from white blood cells.
When they return to Havana,
the doctors are taken
straight to a house
refitted with
a new laboratory...
House 149.
Castro gives them
a simple instruction:
make interferon for Cuba.
They worked constantly every day
until 10:00 or 11:00 at night.
Fidel came here
almost every day,
just making questions.
It was very, very,
very intensive.
It takes scientists
in other countries
as long as a year to replicate
the purification process.
The Cuban doctors
master it in 42 days.
But around the same time,
a new technology,
first developed in California,
is gaining ground worldwide:
genetic engineering.
Castro sends Luis Herrera
to Europe to investigate.
I remained in Europe some time
getting that information.
I came back, and I met Fidel.
And then he started
to make questions
concerning genetic engineering.
The genetic engineering process
Herrera brings back to Cuba
is transforming science
across the globe.
In the laboratory, scientists
remove a section of DNA
from a human cell
that codes for
a specific protein.
They then insert that DNA into
the DNA of a bacterial cell.
As the bacteria replicates,
it carries the code for the
human protein in its own DNA.
And you can put the bacteria
in a fermenter,
and you have millions
of flasks of interferon.
It turned out interferon only
works against a few cancers.
But the process
of making interferon
- took immunotherapy science to a new level.
- Took immunotherapy science to a new level.
Genetic engineering
started a new approach
to fighting cancer
around the world and in Cuba.
By this time,
Castro's ambitions were clear.
That's the first time
I heard him to say
that we can become
a medical power.
That was the beginning
of the whole biotechnology
development in Cuba.
Cuba would go on to build a
world-class biotech industry.
Research, development,
quality control,
and distribution
are all the responsibility
of one government agency:
BioCubaFarma.
They're a small country,
the communication is much
quicker and faster.
They can, um, immediately
make a drug available
to all the patients
who qualify for that drug
and immediately collect the data
on a large number of patients.
Cuba's 30-plus
bio-pharma facilities
hold over 2,000
international patents
for drugs and processes
in use around the world.
But the trade embargo
makes all these treatments
unavailable in the U.S.
Like Vaxira, the cancer vaccine
George Keays has been taking
for nearly two years.
I get one to two calls a week
from people
who have heard about me,
have heard that I'm coming here,
and ask questions, like,
"Where do you get the vaccine?
How did it work for you?"
You know?
I think there are some people
for whom this might not work,
but I think
there are a lot of people
for whom this can be beneficial.
But now American patients
could be on their way
to having access toCuban
cancer treatments legally.
And it all started
with a cold call
to Roswell Park
Comprehensive Cancer Center
in Buffalo, New York.
I was sitting in my office,
and my secretary came
to me and said,
"There's a telephone call
for you
from someone who is from Cuba."
When I picked up the phone,
what she talked about
was the fact that
they have some innovative
approaches in Cuba
that she would like
to discuss with Roswell Park.
I have to tell you, myinitial
response was skeptical.
So, my first question is,
"Why are you talking to us?"
And she talked
about the fact that
this is one of
the few institutions
in the United States
where the discoveries in Cuba
could be taken to the next level
and make sure it benefits
a wide range of patients,
not only in Cuba
but across the world.
Eventually, the researcher
from Cuba's Center
of Molecular Immunology,
or C.I.M.,
is invited to make
a presentation
on the lung cancer vaccine
CIMAvax-EGF,
the same vaccine that
Marta Reymo has been taking.
It is a standing room only
event.
Well, I think, scientists,
we're all a little crazy.
And so we all...
we all want to, uh,
hear something
really interesting.
It sparked curiosity
of how it came to be.
And so, that was what
I recall from it, is, "Wow."
In Cuba, jeez."
Cancer vaccines are already in
development around the world,
but what surprises
Roswell Park researchers is
the science that
makes this vaccine work.
They had thrown out
the first chapter
of any basic immunology textbook
to actually accomplish
the science.
Cuban scientists claim to
havefound a new way to fight cancer
by first getting
the immune system
to do something
it's never supposed to do:
attack a healthy human protein.
The research Cuba presents
atRoswell Park goes back to 1981.
A young scientist
named Rolando Pérez
is investigatingepidermal
growth factor, or EGF.
It's a natural protein
in the body
that tells cells to multiply.
Pérez is one of many
scientists around the world
trying to understand the role
EGF might play in cancer.
We wanted to know
whether human breast tumors
were dependent on EGF
for their growth.
What we found was ahigh
expression of EGF receptors
in about 50% of tumors.
A receptor is a protein molecule
on the cell's outer surface.
When an EGF protein connects
with an EGF receptor
on the cell's surface,
the protein sends a signal
to grow and multiply.
It was really a surprise
to find that there were tumors
which had a high dependence
on EGF.
At Roswell Park,
researchers show
how live cancer cells
use EGF to grow into the
beginnings of a tumor mass.
In the culture that has
epidermal growth factor,
you can see a layer
of lung cancer cells
that over time are
dividing and growing
and getting bigger and bigger.
In the culture that
has the lung cancer cells
but has been depleted of EGF,
you can see that
the lung cancer cells
have in fact stopped growing.
Pérez's research points out
some tumor cells have
thousands more EGF receptors
than healthy cells.
To prevent cancer
from using EGF to grow,
the Cubans came up
with a novel idea:
starve the tumor by removing EGF
from the equation.
To do this, they would have to
vaccinate the body against EGF
and convince the immune system
this normal human protein
is a threat.
But it wouldn't be easy.
If you vaccinate a human being
with human EGF,
nothing happens,
because the immune system
interprets that this is self.
A typical vaccine
includes a weakened dose
of the virus or bacteria
being targeted.
Once it's injected
into the body,
the immune system
produces antibodies
that attach to the invader
and attract other immune cells
to destroy it.
Memory cells remember it
in case it comes back again.
To get the body to recognize EGF
as a threat,
Cuban scientists attached
a protein
from the meningitis bacteria
to the EGF protein.
So, then the invention was
to link human EGF
with a protein that is coming
from a bacteria,
from the meningitis bacteria,
by the way.
And as the bacteria protein
is there,
then the immune system
interpret,
"This is non-self
and dangerous."
The attached bacterial molecule
causes the immune system
to see all EGF as a threat.
Antibodies signal immune cells
to eliminate the EGF.
The idea is to starve
lung cancer cells
of something
they depend on to multiply
but leave enough EGF in the
bodyfor ordinary cells to function.
As it turns out,
CIMAvax is most effective
for lung cancer patients
like Marta,
who already have high levels
of EGF in their blood.
You are making a trick
to the immune system, no?
You trick the immune system,
because you present something
self as if it were non-self.
When Roswell Park researchers
learn the science
behind CIMAvax,
many are convinced
it could be a game-changer.
They urge president and C.E.O.
Candace Johnson
To consider the possibility
of a partnership.
It was really
a couple of individuals
that decided
to really press this.
"And let's,
let's see what we can do.
"Let's reach out to these folks
in Havana
and see if we can establish
somesort of relationship with them."
Then, in 2014...
Good afternoon.
History opens a door.
Today, the United States
of America
is changing its relationship
with the people of Cuba.
President Obama
beginsnormalizing relations with Cuba.
And New York Governor
Andrew Cuomo
leads a trade delegation
to Havana.
So, the governor wanted
to take a group of leaders
from around the state,
and he chose me.
I could bring one person,
and I took Dr. Lee.
So here we all go into Cuba,
we're only there for 36 hours.
And Dr. Lee and I decided
that this was an opportunity
to really do this.
Roswell Park scientists believe
Cuba's CIMAvax could add
to the arsenal of weapons
available for cancer patients.
The Cubans hope for access
toresearch data from Roswell Park
and even technologies that
couldimprove their immunology drugs.
We have limited resources,
because of... we are
in a poor country.
We have also limited resources,
because the best and
the most efficient technology
are usually coming
from the U.S.,
and we don't have
access to that.
One example is this
American-made flow cytometer.
It suspends samples in a fluid
and whisks them
through multiple lasers,
one cell at a time.
Tens of thousands
of cells' characteristics
are rapidly analyzed.
In the U.S.,
the device is standard
for advanced research
and clinical trials.
So, in this case,
we're measuring the T-cells
in the patient's blood
in order to determine what
type of T-cells are present.
One department at Roswell Park
has over 20
of these expensive machines.
The data they could yield
for Cuban research
would be invaluable.
There are only two
such devices at C.I.M.
One is broken.
So, we had this equipment
broke for one year,
because we had to send
the equipment to Germany.
If this equipment has
more than ten percent
of the American component,
we can't buy.
Despite these limitations,
Cuban science makes
important strides,
even as American discoveries
in immunology treatment
continue to lead the world.
For Roswell Park,
a partnership with Cuba
could allow them to combine
C.I.M.'s cancer vaccine
with immunotherapy treatments
already available,
like checkpoint inhibitors.
- What we're realizing now is that
- What we're realizing now is that
You have to combine
immunotherapy agents.
So, we're seeing studies
that are testing vaccine
with immune checkpoint agents.
At Johns Hopkins Kimmel Cancer
Center in Baltimore,
Bruce Toma is being treated
for stage IV pancreatic cancer.
One more.
He's participating
in a clinical trial
combining checkpoint inhibitors
with a cancer vaccine developed
by Dr. Elizabeth Jaffee.
This is how goodyour work has done.
Nobody can believe...
It's, it's so exciting.
That I'm stage IVmetastasized
pancreatic cancer.
I don't know how much
of your scans you've seen.
First one. The first one.
So what we're reallyexcited about
is that you had
all of this tumor here
at the peritoneum.
Mm-hmm.
Your most recent scan,
there's nothing there.
We can't detect it.
It's totally gone.
Oh wow, yes,
I can see the difference.
Immunotherapies are
incredibly expensive.
And not everyone has
the same success as Bruce.
And we don't know why.
If we can understand
why certain patients do benefit
from immunotherapy
while others don't benefit
from treatment,
we can make great leaps forward
in our cancer treatment.
Anything else going on?
Any headaches...
But for now, many patients...
No matter what therapies
they are receiving...
Will likely reach a point
when they run out
of treatment options.
As their cancer grows,
and the treatment
that I'm giving them fails,
I become anxious,
because with every step,
their options become
more and more limited.
Mum, she took the scissors,
and she started just
chopping off her own hair.
I'll never forget it.
My sister and I just stood there
just awestruck.
It was a very
emotional experience.
And Kathy was willing
to try anything.
And it was tough on her
when they, when they said,
"That's it,
there-there is no more,
and treatment would
only make you worse."
But Kathy held the doctor's hand
and said, "I understand."
They say usually
it's three years, the time.
I'm exactly at third year.
The doctor said
I have one more year to live.
It's no pain,
because the needle is so thin.
No, I see, mm-hmm.
Mosquito.
Yeah.
At La Pradera,
oncologists administer
George's Vaxira prescription.
Okay.
George's doctor and close friend
Dr. William Blanchet is
in Havana to lend support.
The cancer was growing,
the cancer markers were
getting bigger on this agent.
His oncologist
increased the dosage;
the cancer continued
to get bigger.
We added the Vaxira,
and his cancer gets smaller.
And so, on the
three-year anniversary
of being diagnosed with horrible
stage IV lung cancer,
this guy runs a ten-K run and
puts an offer down on a house.
Those are things that people
three years into stage IV
lung cancer tend not to do.
But George is not cured.
Cancer continues to be
a daily struggle.
In addition to Vaxira,
he's undergoing a number
of treatments in the U.S.
Despite this, his doctors
recently discovered
a new metastasis in his liver.
It's a hell of a thing
to have to take a risk
with, you know,
your-your wellbeing
that you...
that somebody could say,
"Well, you're breaking the law."
But could Cuban drugs
like Vaxira
become available in the U.S.?
In science, cooperation
is everything.
So if you are isolated,
you are dead in science.
Our legal department saying,
"How are we going to do this?
Is this going to be worth it?"
And I said, "If there's
a two-percent chance"
that the science is right,
we need to be there."
Cuba and Roswell Park come
to an agreement to cooperate.
In 2016, CIMAvax becomes
the first Cuban drug ever
approved by the FDA
for clinical trial in the U.S.
At Roswell Park,
it's being combined with
acheckpoint inhibitor, nivolumab,
that could make CIMAvax
even more effective.
And the flip side is
the way CIMAvax works,
it may make nivolumab
work better as well.
Think of it like, can
one plus one equal to five?
So that's the ultimate
goal of testing.
Two years later, Cuba's Center
of Molecular Immunology
and Roswell Park double down
on their partnership
and make history again.
The president and
C.E.O. of Roswell Park
announced the first-ever
biotech joint venture
between the United States
and Cuba.
We did it!
The two agree to build
a new biotech facility in Cuba
dedicated to cancer drugs,
jointly owned by
Roswell Park and C.I.M.
Eventually, we will
build factories.
And at some point of time
we will reachthe medical community
in Cuba and the U.S.
with new medicinesfor the people.
The embargo will continue to be
one of the biggest challenges
for the Roswell Park-C.I.M.
research partnership.
Even after the FDA approved
clinical trials in 2016,
Roswell Park worried the
embargowould make it almost impossible
to ship CIMAvax safely
from Havana to Buffalo.
So they tried
a test run with water
in a temperature-controlled box.
It actually got from
Havana to Canadian customs;
and the FDA was expecting it,
because we told them there
it would come.
Got to U.S. customs.
Apparently, if you're
on the embargo list
in the United States,
your country is not
in the electronic database.
So, the box went back to Canada
and sat there
for, I think, two days.
So the box is good for holding
temperature for 72 hours.
Nearly 200 hours after
being packaged in Cuba,
the box arrived in Buffalo.
The real vaccine
would have been destroyed.
These kinds of challenges
are critical to overcome
for the research partnership
to succeed.
Both sides are convinced
it's worth it.
Let's come tobrain tumors,
where the data thatwe have is pretty good.
Then there is nothing
in the United States...
It's a precedent-setting event.
You know, these are
American scientists
working so closely
with Cuban scientists.
They are presenting us
with very novel drugs.
CIMAvax has the potential
to work as a vaccine
to prevent
lung-cancer formation,
and that has a substantial
public-health implication.
I hope, I really hope,
that this won't be stopped
because this is
cancer treatment,
and these are American citizens
being treated
by cancer vaccines manufactured
here in this small country.
Even as political tensions rise
between their two countries,
Cuban and American scientists
continue on
in the hopes of
improving cancer treatment
and one day finding a cure.
If we work together
to raise the quality of the life
of our peoples,
that will bring us together.
Science is going to move
relationships forward.
The promise of lifting
theburden of cancer in all peoples
is going to move
the relationship forward.
I'm handling it,
and I want to keep going
because I have things
that I want to do,
I have things I want to see.
I have things I want to...
complete with my children.
I'm so lucky that I see things,
that I feel things on my skin,
and I don't want to lose it.
I want to live
my life the fullest.
If I can't walk,
I'll be on my knees.
If I can't be on my knees, I'll crawl.
But I'll continually
try to get back up.
And that will be my life.
How do you feel today?
Very good, very good.
Very good?
No pain.
Okay.
No pain.
Before going home,
George meets once more
with Dr. Anabely Garcia,
chief of his
Havana medical team.
And, here, we put in
the date that you receive.
You have vaccines
until August, okay?
Yes, that's right. We wait
for you next May or June.
Oh, no, no, no, no, no.
Don't cry.
Thank you.
I'll see you again in May.
Yes, of course.
Hasta luego.
One of the things you learn
is to live in the moment.
I may not be here in six months,
I-I don't know.
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