Il était une fois... la vie (1987–1988): Season 1, Episode 4 - La moelle osseuse - full transcript

[lively music playing]

♪ Is life, is life, that's life ♪

♪ Sing a song of life ♪

♪ Every heartbeat's a miracle ♪

♪ Feel the rhythm growing ♪

♪ Day by day as we go ♪

♪ Look inside, your body is humming ♪

♪ With a million drums that are drumming ♪

♪ Fill your lungs, get ready ♪

♪ Celebrating the joy
That's life ♪

♪ Is life, is life, that's life ♪



♪ Is life, is life, that's life ♪

THE BONE MARROW

[bright music playing]

[narrator] Bone marrow:

an original organ
found throughout the skeleton.

It is the most important
of the blood corpuscle factories.

Every day,
200 billion red blood corpuscles

15 billion white blood corpuscles

and 500 billion platelets are produced.

Everything starts inside
a big master cell,

which regulates its production

according to the blood requirements
of the body.

Many different foods
flow to the cells energy factories.

[sugar shrieking] Hm.



[narrator] These are the ribosomes

or the assembly line tables
of the proteins.

[upbeat music playing]

[nucleotides shouting]

[enzyme laughing]

[chief] Now let me see... Two hundred
multiplied by 314,000 equals... [mumbles]

Mm. Sixteen hundred and 14. Mm.

-No, no, no. That can’t be right."
-Two hundred what, Chief?

Three hundred and 14,000 what, Chief?

Four hundred thousand and, uh... [grunts]

Can’t you see I'm doing arithmetic?
Don't bother me.

-What arithmetic, Chief?
-Huh?

Uhm... The number of nucleotides
we need to make one red blood corpuscle,

you great big idiot.

Then all I have to do
is multiply that figure by 200.

Now, where was I?

-Two hundred what, Chief?
-[grunts]

Two hundred billion red blood cells.

The system must produce 200 billion
red blood corpuscles a day. Get that?

Two, three, four...

Two hundred billion!
That's a lot; really a lot.

[Maestro snoring]

[ping]

[assistant] Hey, don't you think
it’s time to warn the Maestro?

[assistant 2] The maestro?
But can't you see he's occupied?

Oh well...

That's his way of concentrating, you see.

-Look! There.
-[ping]

-[assistant 2] So what?
-Well, we're nearly at 200 billion.

Two hundred billion what?

Two hundred billion red blood cells;
that's our daily quota.

That’s what our body needs.

-[ping]
-[snorting noise]

[alarm blaring]

What's happening? [pained yelp]

-[assistant 2 yelps in pain]
-[ping]

-[pained yelping]
-What's the matter with you?

You mustn’t kick the equipment.

Just look what you've done!
Because of you, there's one too many.

[Maestro] Don't worry, you two.
First of all, life is order, right?

Give or take a unit of course. [chuckles]

But always respect the equipment,
that's part of the order.

-[bright music playing]
-[rumbling]

[deep breath and sighs]

[chief] Ninety-nine, 200 billion.

-All present and correct.
-[corpuscle] Wait for me!

See, here I am.

[shouts]

That’s 200 billion plus one.

[laughing and cheering]

[Globus] Ah, the little ones
come to relieve us.

What a joy it is to see them.

[chuckling]

[silly giggling]

-[corpuscle coos]
-[Globus laughs]

[Globus] There you are, little corpuscles.
Now you'll be able to circulate oxygen

just like the bigger red blood cells.

-[Hemo] Huh?
-[giggling]

[Maestro] Everything is settled
as far as the red corpuscles,

our oxygen carriers, are concerned.

Let's take a look
at the white blood cells,

our body's police force. Hm.

We need them all the time.
Let's see. Where are they?

-[humming]
-[alarm sounding]

-[Maestro] Hm.
-[voice] Maestro why don’t you look here?

But who allowed that to happen? Ooh!

Yes, of course, 15 billion of them.

Anyway, Maestro,
it's all done automatically.

The production is automatic, true,
but we must monitor it all the time.

An error here could be fatal.

Why is that, Maestro?

The white blood cells have
powerful weapons to defend the body.

If there's an error in programming,

their weapons can be turned
on the body itself, you see.

But how on earth
could that kind of error happen?

We can’t say, it's still a mystery.
Everything is programmed

in the chromosomes.

But the plan can be disrupted.
That's why we keep watch.

[magical sounds]

[Maestro] You see, all the programming
is done here in the chromosomes.

[scraping noise]

-[silly noise]
-[shouts]

[laughs]

Oh ! Stop that stupid game immediately.
Do you hear me?

[shouts]

[laughing and indistinct talking]

Oh, but he's crazy.

He's fooling around
with heredity programming.

This is insane, quite insane!

Restriction enzymes, ligase, enzymes,
to work immediately!

We've got to repair this at once. [groans]

You there!

[nervous] Yes?

[Maestro] Go and have yourself
recycled immediately.

And never play with genes again,
do you hear!

[sulking noises]

Cut here, before the T.

Glue here, after the A.

[enzyme 6] Cut again,
the C is not in the right place.

[enzyme 7] Nor is the Double G.

Good work, now let's verify
the DNA message.

Excellent repair work;
just like the original.

Send an RNA messenger to have more
white corpuscles produced. Thank you.

[giggling]

[scraping noise]

[deep breathing]

[laughing and cheering]

[yawns] Fifteen billion white blood cells.

[moans] Now,
for a little well-earned rest.

-[alarm beeping]
-[snoring]

Maestro! Maestro! We still have to make
500 billion platelets.

[giggling]

-[lively music playing]
-[laughing]

[young hemo] Tell me, where can I go
to load up some more oxygen?

I’ve still got some room.

[Hemo] You'll have to wait
till we get to the lungs.

First, we must deliver the oxygen
we are carrying to the cells,

and then we must
get rid of the carbon dioxide.

[Globine] Here,
you can have a bit of my oxygen.

We must share everything, mustn't we?

[giggles]

Huh?

[laughing]

[laughing and cheering]

[Hemo] Oh, these platelets!
They think only of having fun.

[laughing]

[Peter Jr.] This is Captain Peter Junior.

Traffic is moving steadily in the sector
without any problems.

All our body sentinels
are at their posts.

Nothing to report, Colonel.

[Peter] Okay, Captain.

We'll make use of this opportunity,

shall we, to give our young pilots
a bit of practice.

Flu viruses are reported in Zone 14,
the mucus membrane of the nose.

There aren't too many of them,
and anyway, we're vaccinated.

So give instructions to get rid of them
as quickly as possible.

l will do so at once, Colonel.

Calling B Lymphocyte XO unit.

Calling unit XO. Flu virus alert,

type unknown.
Zone 14, nasal mucus membrane.

Immediate recognizance. Over and out.

[voice] Enemy reported in Zone 14
of nasal mucus.

Flu virus, type unknown.
Immediate verification.

All able B lymphocytes,
take off immediately.

Take off immediately!

[murmuring]

[pilot] Come on.

[pilot] Zone 14,
nasal mucus, straight ahead.

[rumbling]

[grunting and groaning]

[wicked laugh]

[pilot 1] I ‘ve never seen
this kind of virus before.

[pilot 2] Neither have I.

[girl pilot] It's okay.
I know exactly what they are.

Everything is under control.
Well, you can go back now.

You might as well go
and finish your breakfast.

Antibodies specific to virus 113 B, ready?

Let's get them!

Okay, now it's time to multiply.

[playful music playing]

[pained yelping] Oh, no.

[screams]

Exercise concluded
without difficulty Colonel.

Vaccination proved 100% effective.

Macrophages will clear the site.
Over and out.

Huh? Huh?

This is a general alert. General alert.

There's a rebellion
in the body police force.

Our troops are no longer obeying orders.

[tense music playing]

[rumbling]

[laughing]

[shouting]

[cop 1] White blood cells
and more white blood cells.

An awful lot of them,
don't you think?

[cop 2] That’s right, but surely they
must know what they're doing up there.

[machine rumbling]

[Maestro] I don't understand.

We should now be busy making platelets,
but we're stuck with white blood cells.

But maybe we need a
lot of white blood cells.

A lot? But just look over there.

We've got far too many,
15 times too many.

Calling restriction enzymes. It's
absolutely essential to reduce production.

Repair immediately! Urgent! Urgent!
And [stutters] hurry up.

Here, you must cut up here.

I just can't manage it. [grunts]

[gloomy music playing]

[enzyme 2] Neither can I.

[Chief] Do you see the look
on their faces?

Look at their faces!

It's not normal. I tell you, not normal.

Come.

Stop. Stop. You're blocking the
traffic.

Now, you must go this way.

You must follow the rules,
like everybody else.

[leader] Follow the rules?
We don't know any.

[grunting and groaning]

Where are you going? What are you up to?

[grunting and groaning]

[Jumbo Jr.] Just a minute please;
your HLA cards.

Here's my card. Do you dig?

[Jumbo Jr.] No, I don't "dig".
You are different.

You're not the same type,
not for this body.

Maybe you're the one
who’s not the same type.

[chuckles] Come on, boys!

[rumbling and grumbling]

[shouts]

-Yes, come on, let’s go.
-[shocked gasps]

[shouting]

[grunts]

[laughing and mumbling]

[Globus] We were near the heart
when this valve closed...

and blocked my way. Imagine the situation.

After an emotional moment or two,
when I thought I was a goner...

-[grumbling]
-[Hemo] What?

[crowd shrieking]

[salt and corpuscle]
Who are these savages?

[corpuscle 2] What's going on?

Look at these cops. I don't believe it!
Who do they think they are.

[shouting and grumbling]

Wait. Wait! [screams]

No! Don't hurt me.

[grumbling and shouting]

Goodness! What dreadful behavior
from the police.

I wonder if they're normal.

What do you mean, normal?

When the white blood cells attack
the population of their own organism,

it's not normal. It's an illness.

-That's what I think.
-Is that bad?

Oh yes, that can be very bad.

[shrieks]

-Oh! They've gone mad, it's anarchy.
-[sobbing]

I don't feel good, I feel sick.

[Pierrette Jr. whimpers] I feel sick,
I don't feel good.

I hurt, Mummy, I hurt all over.

[Pierrette] Hm?

You've got a temperature, little one.
Lie down and I will call the doctor.

-[melancholic music playing]
-[doctor] Ooh, 40! That's high.

Tell me, little girl,
where are you hurting most?

Everywhere. My legs, they hurt,
and my neck.

[Pierrette] Well, Doctor?

I am not sure;
we'll have to do a blood test.

Will that hurt?

-No, it's just a tiny little prick.
-[sighs]

There you are.

Now, we will have this analyzed
to see what's making you miserable.

l will be back soon.

Hmm, white blood cells rioting.
The anarchists! [scoffs]

Is it serious, Doctor?

Yes, Pierrette, very.
A disease of the blood: leukemia.

The white blood cells are unbalanced,
they've become attackers,

not protectors.

What can we do, Doctor?

We'll destroy the bad elements
in the blood,

and unfortunately, some good ones too.

But let me reassure you that today
we can often cure these diseases,

and your young Peter
will prove to be a great help.

But now, we must
move her to a sterile room.

There's no doubt about it:
this is very serious anemia.

Destruction of red blood cells
and platelets

and rapid multiplication
of rampant white blood cells.

We must hurry.
Destroy all the corpuscles.

Fortunately, we're well-armed. Hm.

[feel-good music playing]

[upbeat music playing]

-What has happened?
-Oh!

-You must know, surely.
-As I told you, dear,

it's a very serious disease of the blood.

Are we all going to die?

We probably will. But if all goes well,
the body won't die.

What? Doesn’t it need us?

No, the body will have to make
more of our own kind.

Life's impossible without us.

So everything will be just the same.

And we’ll still all carry on
sharing oxygen?

-Yes. Hmm.
-Oh! I love fresh air.

[shocked gasp] Oh, look. But [stutters]
it's not possible. Look out!

-[humming noise]
-[gloomy music playing]

Run, run, run, run.

[yelling]

[upbeat music playing]

[gushing noise]

[screams]

[gushing noise]

We are going to be drowned.

[shouting]

[shouts]

[loud rumble]

White cells,
the body's sentinels, destroyed.

Red corpuscles,
the energy carriers, decimated.

The bone-marrow factory, destroyed.
Production: zero.

Organism's defense: zero.

The advantage of the situation is that all
the wild white cells have been destroyed

and their factory's in ruins.
Now we can start again.

[feel-good music playing]

The anarchistic cells have been eliminated
and production ended,

but now she has no defense
against germs and microbes.

We must provide her with other defenses,

and nobody can do that
better than her brother.

-What do you mean?
-Well, he can give her bone marrow cells.

They're healthy and have the same HLA,

or, uhm, characteristics as his sisters.

They'll help us reconstruct
what we have destroyed.

Ah, here's young Peter.

You'll see, it won't be sore. [chuckles]
Just a tiny little prick there!

[Peter] Hm. I am scared of injections,
but I do want her cured,

so go ahead.

Oh, Peter!

[feel-good music playing]

[laughing and mumbling]

[rumbling]

[laughing and cheering]

[alarm beeping]

And now, Maestro?

And now we must wait
for one of life's miracles.

The cells I have injected will go
on an extraordinarily long journey.

See, from the vein in the arm,
they go up to the heart.

[beating sound]

From there, the right ventricle pushes
them into the pulmonary aorta

and they pass through the lungs.

Then, they're projected
into general circulation,

the big arteries
and the fine arteries.

[upbeat music playing]

They carry on and only stop

when they find themselves
in the bone marrow.

It's as if they've always known

that they had to go there,
and nowhere else. Hm.

[laughing and cheering]

It's working! It's working!

The production lines
are functioning perfectly.

We've won! We've won! We've won!

Just look at that! Everything in order.

You're fine. You'll have to be patient
for a while but everything's fine.

[laughing and shouting]

Whoa!

[chuckles] Here you are.

Thanks.

Ah, oxygen, I love it so!

HLA cards, please!

Very well, you may carry on now.

Everything in order, Lieutenant?

Everything's fine;
I think we're quite safe now.

[hearty laughter]

[lively music playing]